EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these formations are required for signalling.

Saved in:
Bibliographic Details
Main Authors: Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e

Similar Items