FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients

Abstract Background Sarcoidosis is granulomatous disease of unknown origin affecting organ function and quality of life. The King’s Sarcoidosis Questionnaire (KSQ) serves as a tool to assess quality of life in sarcoidosis patients with general health and organ specific domains. A German translation...

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Autores principales:	Björn Christian Frye, Laura Potasso, Erik Farin-Glattacker, Surrinder Birring, Joachim Müller-Quernheim, Jonas Christian Schupp
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Sarcoidosis Quality of life King’s Sarcoidosis Questionnaire Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/410a89b349b84293a110bc6dc9be554e
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spelling	oai:doaj.org-article:410a89b349b84293a110bc6dc9be554e2021-12-05T12:23:30ZFeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients10.1186/s12890-021-01761-71471-2466https://doaj.org/article/410a89b349b84293a110bc6dc9be554e2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01761-7https://doaj.org/toc/1471-2466Abstract Background Sarcoidosis is granulomatous disease of unknown origin affecting organ function and quality of life. The King’s Sarcoidosis Questionnaire (KSQ) serves as a tool to assess quality of life in sarcoidosis patients with general health and organ specific domains. A German translation has been validated in a German cohort. In this study we assessed, whether clinical parameters influence KSQ scores. Methods Clinical data (e.g. lung function, organ impairment, serological parameters) for the German validation cohort were extracted from clinical charts and investigated by correlation and linear regression analyses. Results KSQ subdomain scores were generally lower in patients with respective organ manifestation or on current therapy. LUNG subdomain was significantly predicted by lung functional parameters, however for general health status, only FeV1 exerted significant influence. GHS was not influenced by serological parameters, but was significantly negatively correlated with body mass index (BMI). KSQ provides additional information beyond lung function, clinical or serological parameters in sarcoidosis patients. Notably, high BMI is significantly negatively associated with patients’ well-being as measured by KSQ-GHS. Conclusion This observation may direct further studies investigating the effect of obesity on sarcoidosis-related quality of life and strategies to intervene with steroid-sparing therapies and measures of life style modifications. Trial registration This study was registered in the German Clinical Trials Register (reference number DRKS00010072). Registered January 2016.Björn Christian FryeLaura PotassoErik Farin-GlattackerSurrinder BirringJoachim Müller-QuernheimJonas Christian SchuppBMCarticleSarcoidosisQuality of lifeKing’s Sarcoidosis QuestionnaireDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sarcoidosis Quality of life King’s Sarcoidosis Questionnaire Diseases of the respiratory system RC705-779
spellingShingle	Sarcoidosis Quality of life King’s Sarcoidosis Questionnaire Diseases of the respiratory system RC705-779 Björn Christian Frye Laura Potasso Erik Farin-Glattacker Surrinder Birring Joachim Müller-Quernheim Jonas Christian Schupp FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
description	Abstract Background Sarcoidosis is granulomatous disease of unknown origin affecting organ function and quality of life. The King’s Sarcoidosis Questionnaire (KSQ) serves as a tool to assess quality of life in sarcoidosis patients with general health and organ specific domains. A German translation has been validated in a German cohort. In this study we assessed, whether clinical parameters influence KSQ scores. Methods Clinical data (e.g. lung function, organ impairment, serological parameters) for the German validation cohort were extracted from clinical charts and investigated by correlation and linear regression analyses. Results KSQ subdomain scores were generally lower in patients with respective organ manifestation or on current therapy. LUNG subdomain was significantly predicted by lung functional parameters, however for general health status, only FeV1 exerted significant influence. GHS was not influenced by serological parameters, but was significantly negatively correlated with body mass index (BMI). KSQ provides additional information beyond lung function, clinical or serological parameters in sarcoidosis patients. Notably, high BMI is significantly negatively associated with patients’ well-being as measured by KSQ-GHS. Conclusion This observation may direct further studies investigating the effect of obesity on sarcoidosis-related quality of life and strategies to intervene with steroid-sparing therapies and measures of life style modifications. Trial registration This study was registered in the German Clinical Trials Register (reference number DRKS00010072). Registered January 2016.
format	article
author	Björn Christian Frye Laura Potasso Erik Farin-Glattacker Surrinder Birring Joachim Müller-Quernheim Jonas Christian Schupp
author_facet	Björn Christian Frye Laura Potasso Erik Farin-Glattacker Surrinder Birring Joachim Müller-Quernheim Jonas Christian Schupp
author_sort	Björn Christian Frye
title	FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
title_short	FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
title_full	FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
title_fullStr	FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
title_full_unstemmed	FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
title_sort	fev1 and bmi influence king’s sarcoidosis questionnaire score in sarcoidosis patients
publisher	BMC
publishDate	2021
url	https://doaj.org/article/410a89b349b84293a110bc6dc9be554e
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_version_	1718371953110155264

FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients

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