Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer

This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgica...

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Autores principales:	Hyeong Chan Shin, Incheol Seo, Hasong Jeong, Sang Jun Byun, Shin Kim, Sung Uk Bae, Sun Young Kwon, Hye Won Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumor-associated macrophages colorectal cancer tumor microenvironment prognosis Science Q
Acceso en línea:	https://doaj.org/article/410c13e5a7e24d1cb9595a40d4c6e8bb
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spelling	oai:doaj.org-article:410c13e5a7e24d1cb9595a40d4c6e8bb2021-11-25T18:11:29ZPrognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer10.3390/life111112402075-1729https://doaj.org/article/410c13e5a7e24d1cb9595a40d4c6e8bb2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1240https://doaj.org/toc/2075-1729This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.Hyeong Chan ShinIncheol SeoHasong JeongSang Jun ByunShin KimSung Uk BaeSun Young KwonHye Won LeeMDPI AGarticletumor-associated macrophagescolorectal cancertumor microenvironmentprognosisScienceQENLife, Vol 11, Iss 1240, p 1240 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor-associated macrophages colorectal cancer tumor microenvironment prognosis Science Q
spellingShingle	tumor-associated macrophages colorectal cancer tumor microenvironment prognosis Science Q Hyeong Chan Shin Incheol Seo Hasong Jeong Sang Jun Byun Shin Kim Sung Uk Bae Sun Young Kwon Hye Won Lee Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
description	This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.
format	article
author	Hyeong Chan Shin Incheol Seo Hasong Jeong Sang Jun Byun Shin Kim Sung Uk Bae Sun Young Kwon Hye Won Lee
author_facet	Hyeong Chan Shin Incheol Seo Hasong Jeong Sang Jun Byun Shin Kim Sung Uk Bae Sun Young Kwon Hye Won Lee
author_sort	Hyeong Chan Shin
title	Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_short	Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_full	Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_fullStr	Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_full_unstemmed	Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer
title_sort	prognostic impact of tumor-associated macrophages on long-term oncologic outcomes in colorectal cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/410c13e5a7e24d1cb9595a40d4c6e8bb
work_keys_str_mv	AT hyeongchanshin prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT incheolseo prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT hasongjeong prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT sangjunbyun prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT shinkim prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT sungukbae prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT sunyoungkwon prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer AT hyewonlee prognosticimpactoftumorassociatedmacrophagesonlongtermoncologicoutcomesincolorectalcancer
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Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer

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