Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

Acetylcholine (ACh), released in the hippocampus from fibers originating in the medial septum/diagonal band of Broca (MSDB) complex, is crucial for learning and memory. The CA2 region of the hippocampus has received increasing attention in the context of social memory. However, the contribution of A...

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Autores principales:	Domenico Pimpinella, Valentina Mastrorilli, Corinna Giorgi, Silke Coemans, Salvatore Lecca, Arnaud L Lalive, Hannah Ostermann, Elke C Fuchs, Hannah Monyer, Andrea Mele, Enrico Cherubini, Marilena Griguoli
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	hippocampus social memory CA2 region acetylcholine nicotinic receptors medial septum Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/410c1485f24f4040804c55fc6f42fc42
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spelling	oai:doaj.org-article:410c1485f24f4040804c55fc6f42fc422021-11-15T05:17:53ZSeptal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition10.7554/eLife.655802050-084Xe65580https://doaj.org/article/410c1485f24f4040804c55fc6f42fc422021-10-01T00:00:00Zhttps://elifesciences.org/articles/65580https://doaj.org/toc/2050-084XAcetylcholine (ACh), released in the hippocampus from fibers originating in the medial septum/diagonal band of Broca (MSDB) complex, is crucial for learning and memory. The CA2 region of the hippocampus has received increasing attention in the context of social memory. However, the contribution of ACh to this process remains unclear. Here, we show that in mice, ACh controls social memory. Specifically, MSDB cholinergic neurons inhibition impairs social novelty discrimination, meaning the propensity of a mouse to interact with a novel rather than a familiar conspecific. This effect is mimicked by a selective antagonist of nicotinic AChRs delivered in CA2. Ex vivo recordings from hippocampal slices provide insight into the underlying mechanism, as activation of nAChRs by nicotine increases the excitatory drive to CA2 principal cells via disinhibition. In line with this observation, optogenetic activation of cholinergic neurons in MSDB increases the firing of CA2 principal cells in vivo. These results point to nAChRs as essential players in social novelty discrimination by controlling inhibition in the CA2 region.Domenico PimpinellaValentina MastrorilliCorinna GiorgiSilke CoemansSalvatore LeccaArnaud L LaliveHannah OstermannElke C FuchsHannah MonyerAndrea MeleEnrico CherubiniMarilena GriguolieLife Sciences Publications Ltdarticlehippocampussocial memoryCA2 regionacetylcholinenicotinic receptorsmedial septumMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hippocampus social memory CA2 region acetylcholine nicotinic receptors medial septum Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	hippocampus social memory CA2 region acetylcholine nicotinic receptors medial septum Medicine R Science Q Biology (General) QH301-705.5 Domenico Pimpinella Valentina Mastrorilli Corinna Giorgi Silke Coemans Salvatore Lecca Arnaud L Lalive Hannah Ostermann Elke C Fuchs Hannah Monyer Andrea Mele Enrico Cherubini Marilena Griguoli Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
description	Acetylcholine (ACh), released in the hippocampus from fibers originating in the medial septum/diagonal band of Broca (MSDB) complex, is crucial for learning and memory. The CA2 region of the hippocampus has received increasing attention in the context of social memory. However, the contribution of ACh to this process remains unclear. Here, we show that in mice, ACh controls social memory. Specifically, MSDB cholinergic neurons inhibition impairs social novelty discrimination, meaning the propensity of a mouse to interact with a novel rather than a familiar conspecific. This effect is mimicked by a selective antagonist of nicotinic AChRs delivered in CA2. Ex vivo recordings from hippocampal slices provide insight into the underlying mechanism, as activation of nAChRs by nicotine increases the excitatory drive to CA2 principal cells via disinhibition. In line with this observation, optogenetic activation of cholinergic neurons in MSDB increases the firing of CA2 principal cells in vivo. These results point to nAChRs as essential players in social novelty discrimination by controlling inhibition in the CA2 region.
format	article
author	Domenico Pimpinella Valentina Mastrorilli Corinna Giorgi Silke Coemans Salvatore Lecca Arnaud L Lalive Hannah Ostermann Elke C Fuchs Hannah Monyer Andrea Mele Enrico Cherubini Marilena Griguoli
author_facet	Domenico Pimpinella Valentina Mastrorilli Corinna Giorgi Silke Coemans Salvatore Lecca Arnaud L Lalive Hannah Ostermann Elke C Fuchs Hannah Monyer Andrea Mele Enrico Cherubini Marilena Griguoli
author_sort	Domenico Pimpinella
title	Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
title_short	Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
title_full	Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
title_fullStr	Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
title_full_unstemmed	Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
title_sort	septal cholinergic input to ca2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/410c1485f24f4040804c55fc6f42fc42
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Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

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