Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate

It is known that the five carbon platform chemical glutarate can be catabolized by the glutaryl-CoA dehydrogenation pathway. Here, the authors discover an additional glutarate catabolic pathway involving l-2-hydroxyglutarate and show increased glutarate production by blocking both catabolic pathways...

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Autores principales:	Manman Zhang, Chao Gao, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma, Ping Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/410d386a718d45bba309100ab02c7216
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spelling	oai:doaj.org-article:410d386a718d45bba309100ab02c72162021-12-02T13:27:31ZIncreased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate10.1038/s41467-018-04513-02041-1723https://doaj.org/article/410d386a718d45bba309100ab02c72162018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04513-0https://doaj.org/toc/2041-1723It is known that the five carbon platform chemical glutarate can be catabolized by the glutaryl-CoA dehydrogenation pathway. Here, the authors discover an additional glutarate catabolic pathway involving l-2-hydroxyglutarate and show increased glutarate production by blocking both catabolic pathways.Manman ZhangChao GaoXiaoting GuoShiting GuoZhaoqi KangDan XiaoJinxin YanFei TaoWen ZhangWenyue DongPan LiuChen YangCuiqing MaPing XuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manman Zhang Chao Gao Xiaoting Guo Shiting Guo Zhaoqi Kang Dan Xiao Jinxin Yan Fei Tao Wen Zhang Wenyue Dong Pan Liu Chen Yang Cuiqing Ma Ping Xu Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
description	It is known that the five carbon platform chemical glutarate can be catabolized by the glutaryl-CoA dehydrogenation pathway. Here, the authors discover an additional glutarate catabolic pathway involving l-2-hydroxyglutarate and show increased glutarate production by blocking both catabolic pathways.
format	article
author	Manman Zhang Chao Gao Xiaoting Guo Shiting Guo Zhaoqi Kang Dan Xiao Jinxin Yan Fei Tao Wen Zhang Wenyue Dong Pan Liu Chen Yang Cuiqing Ma Ping Xu
author_facet	Manman Zhang Chao Gao Xiaoting Guo Shiting Guo Zhaoqi Kang Dan Xiao Jinxin Yan Fei Tao Wen Zhang Wenyue Dong Pan Liu Chen Yang Cuiqing Ma Ping Xu
author_sort	Manman Zhang
title	Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
title_short	Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
title_full	Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
title_fullStr	Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
title_full_unstemmed	Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
title_sort	increased glutarate production by blocking the glutaryl-coa dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/410d386a718d45bba309100ab02c7216
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Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate

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