Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma

Background: Nodular squamous cell carcinoma (SCC) and keratoacanthoma (KA) may mimic a variety of other benign and malignant non-pigmented nodules. Objectives: To analyze the dermoscopic characteristics of nodular SCC and KA. Patients/Methods: Retrospective analysis of 50 nodular SCCs and 8 K...

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Autores principales:	Matthew J. Lin, Yan Pan, John W. Kelly
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2014
Materias:	dermoscopy diagnosis nodules squamous cell carcinoma keratoacanthoma Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/410d4877429847dca043b7807d744175
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spelling	oai:doaj.org-article:410d4877429847dca043b7807d7441752021-11-17T08:32:23ZDermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma10.5826/dpc.0402a022160-9381https://doaj.org/article/410d4877429847dca043b7807d7441752014-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/877https://doaj.org/toc/2160-9381 Background: Nodular squamous cell carcinoma (SCC) and keratoacanthoma (KA) may mimic a variety of other benign and malignant non-pigmented nodules. Objectives: To analyze the dermoscopic characteristics of nodular SCC and KA. Patients/Methods: Retrospective analysis of 50 nodular SCCs and 8 KAs collected from a tertiary dermatology referral center and a private dermatology practice in Melbourne, Australia, between 1 September 2009 and 1 October 2012. All lesions were nodules; defined as firm, elevated, round, palpable tumors with a diameter of 5 mm or more. Clinical and dermoscopic images were evaluated by two examiners in consensus. Results: Signs of keratinization were frequently observed and included keratin crust/scale (90% of SCCs, 100% of KAs), central keratin mass (32% of SCCs, 88% of KAs), white structureless areas (66% of SCCs, 50% of KAs), white circles (32% of SCCs, 38% of KAs) and white keratin pearls (14% of SCCs, 12% of KAs). Hemorrhage was present in 72% of SCCs and 88% of KAs and preferentially occurred centrally and in areas of keratinization. For nodular SCCs and KAs, we observed glomerular vessels (42% and 25% respectively), linear irregular vessels (36% and 25% respectively), atypical vessels (30% and 38% respectively) and hairpin vessels (30% and 25% respectively). Conclusions: Hemorrhage, keratinization and vascular features (glomerular, hairpin and linear irregular morphologies) are useful in diagnosing both nodular SCC and KA. Further research on the comparative dermoscopic characteristics of a range of amelanotic nodules is important in order to improve diagnosis of these clinically challenging tumors. Matthew J. LinYan PanJohn W. KellyMattioli1885articledermoscopydiagnosisnodulessquamous cell carcinomakeratoacanthomaDermatologyRL1-803ENDermatology Practical & Conceptual (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermoscopy diagnosis nodules squamous cell carcinoma keratoacanthoma Dermatology RL1-803
spellingShingle	dermoscopy diagnosis nodules squamous cell carcinoma keratoacanthoma Dermatology RL1-803 Matthew J. Lin Yan Pan John W. Kelly Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
description	Background: Nodular squamous cell carcinoma (SCC) and keratoacanthoma (KA) may mimic a variety of other benign and malignant non-pigmented nodules. Objectives: To analyze the dermoscopic characteristics of nodular SCC and KA. Patients/Methods: Retrospective analysis of 50 nodular SCCs and 8 KAs collected from a tertiary dermatology referral center and a private dermatology practice in Melbourne, Australia, between 1 September 2009 and 1 October 2012. All lesions were nodules; defined as firm, elevated, round, palpable tumors with a diameter of 5 mm or more. Clinical and dermoscopic images were evaluated by two examiners in consensus. Results: Signs of keratinization were frequently observed and included keratin crust/scale (90% of SCCs, 100% of KAs), central keratin mass (32% of SCCs, 88% of KAs), white structureless areas (66% of SCCs, 50% of KAs), white circles (32% of SCCs, 38% of KAs) and white keratin pearls (14% of SCCs, 12% of KAs). Hemorrhage was present in 72% of SCCs and 88% of KAs and preferentially occurred centrally and in areas of keratinization. For nodular SCCs and KAs, we observed glomerular vessels (42% and 25% respectively), linear irregular vessels (36% and 25% respectively), atypical vessels (30% and 38% respectively) and hairpin vessels (30% and 25% respectively). Conclusions: Hemorrhage, keratinization and vascular features (glomerular, hairpin and linear irregular morphologies) are useful in diagnosing both nodular SCC and KA. Further research on the comparative dermoscopic characteristics of a range of amelanotic nodules is important in order to improve diagnosis of these clinically challenging tumors.
format	article
author	Matthew J. Lin Yan Pan John W. Kelly
author_facet	Matthew J. Lin Yan Pan John W. Kelly
author_sort	Matthew J. Lin
title	Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
title_short	Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
title_full	Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
title_fullStr	Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
title_full_unstemmed	Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
title_sort	dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma
publisher	Mattioli1885
publishDate	2014
url	https://doaj.org/article/410d4877429847dca043b7807d744175
work_keys_str_mv	AT matthewjlin dermoscopiccharacteristicsofnodularsquamouscellcarcinomaandkeratoacanthoma AT yanpan dermoscopiccharacteristicsofnodularsquamouscellcarcinomaandkeratoacanthoma AT johnwkelly dermoscopiccharacteristicsofnodularsquamouscellcarcinomaandkeratoacanthoma
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Dermoscopic characteristics of nodular squamous cell carcinoma and keratoacanthoma

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