Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility

People with a genetic deletion of the 15q11.2 locus are at increased risk for psychiatric disorders and white matter disturbances, but the gene(s) responsible are unclear. Here, the authors show that low dosage of CYFIP1, present in the human 15q11.2 region, alters white matter structure and cogniti...

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Autores principales:	Ana I. Silva, Josephine E. Haddon, Yasir Ahmed Syed, Simon Trent, Tzu-Ching E. Lin, Yateen Patel, Jenny Carter, Niels Haan, Robert C. Honey, Trevor Humby, Yaniv Assaf, Michael J. Owen, David E. J. Linden, Jeremy Hall, Lawrence S. Wilkinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/411296870f6b40bf8e1be35dea45f741
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spelling	oai:doaj.org-article:411296870f6b40bf8e1be35dea45f7412021-12-02T17:01:50ZCyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility10.1038/s41467-019-11119-72041-1723https://doaj.org/article/411296870f6b40bf8e1be35dea45f7412019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11119-7https://doaj.org/toc/2041-1723People with a genetic deletion of the 15q11.2 locus are at increased risk for psychiatric disorders and white matter disturbances, but the gene(s) responsible are unclear. Here, the authors show that low dosage of CYFIP1, present in the human 15q11.2 region, alters white matter structure and cognition in rats.Ana I. SilvaJosephine E. HaddonYasir Ahmed SyedSimon TrentTzu-Ching E. LinYateen PatelJenny CarterNiels HaanRobert C. HoneyTrevor HumbyYaniv AssafMichael J. OwenDavid E. J. LindenJeremy HallLawrence S. WilkinsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ana I. Silva Josephine E. Haddon Yasir Ahmed Syed Simon Trent Tzu-Ching E. Lin Yateen Patel Jenny Carter Niels Haan Robert C. Honey Trevor Humby Yaniv Assaf Michael J. Owen David E. J. Linden Jeremy Hall Lawrence S. Wilkinson Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
description	People with a genetic deletion of the 15q11.2 locus are at increased risk for psychiatric disorders and white matter disturbances, but the gene(s) responsible are unclear. Here, the authors show that low dosage of CYFIP1, present in the human 15q11.2 region, alters white matter structure and cognition in rats.
format	article
author	Ana I. Silva Josephine E. Haddon Yasir Ahmed Syed Simon Trent Tzu-Ching E. Lin Yateen Patel Jenny Carter Niels Haan Robert C. Honey Trevor Humby Yaniv Assaf Michael J. Owen David E. J. Linden Jeremy Hall Lawrence S. Wilkinson
author_facet	Ana I. Silva Josephine E. Haddon Yasir Ahmed Syed Simon Trent Tzu-Ching E. Lin Yateen Patel Jenny Carter Niels Haan Robert C. Honey Trevor Humby Yaniv Assaf Michael J. Owen David E. J. Linden Jeremy Hall Lawrence S. Wilkinson
author_sort	Ana I. Silva
title	Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
title_short	Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
title_full	Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
title_fullStr	Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
title_full_unstemmed	Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
title_sort	cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/411296870f6b40bf8e1be35dea45f741
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Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility

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