Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery

Wence Ding, Lin GuoKey Laboratory of Mesoscopic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of ChinaAbstract: Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loadin...

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Autores principales:	Ding W, Guo L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4112cb6cc5ed434798d6208a55f57129
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spelling	oai:doaj.org-article:4112cb6cc5ed434798d6208a55f571292021-12-02T05:32:00ZImmobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery1176-91141178-2013https://doaj.org/article/4112cb6cc5ed434798d6208a55f571292013-12-01T00:00:00Zhttp://www.dovepress.com/immobilized-transferrin-fe3o4sio2-nanoparticle-with-high-doxorubicin-l-a15153https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Wence Ding, Lin GuoKey Laboratory of Mesoscopic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of ChinaAbstract: Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high trapping efficiency for magnetic targeting, TfDMP exhibits a Tf receptor-targeting function. Moreover, the DOX loading percentage of TfDMP is high, and can be controlled by adjusting the reactant ratio. TfDMP presents a narrow size distribution, and is sensitive to pH for drug release. Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. This study provides an efficient method for the dual-targeted delivery of therapeutic agents to tumors, with controlled low carrier toxicity and high efficiency.Keywords: transferrin, Fe3O4@SiO2, nanoparticle, doxorubicin, targeted tumorDing WGuo LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4631-4639 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ding W Guo L Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
description	Wence Ding, Lin GuoKey Laboratory of Mesoscopic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of ChinaAbstract: Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high trapping efficiency for magnetic targeting, TfDMP exhibits a Tf receptor-targeting function. Moreover, the DOX loading percentage of TfDMP is high, and can be controlled by adjusting the reactant ratio. TfDMP presents a narrow size distribution, and is sensitive to pH for drug release. Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. This study provides an efficient method for the dual-targeted delivery of therapeutic agents to tumors, with controlled low carrier toxicity and high efficiency.Keywords: transferrin, Fe3O4@SiO2, nanoparticle, doxorubicin, targeted tumor
format	article
author	Ding W Guo L
author_facet	Ding W Guo L
author_sort	Ding W
title	Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
title_short	Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
title_full	Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
title_fullStr	Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
title_full_unstemmed	Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
title_sort	immobilized transferrin fe3o4@sio2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/4112cb6cc5ed434798d6208a55f57129
work_keys_str_mv	AT dingw immobilizedtransferrinfe3o4sio2nanoparticlewithhighdoxorubicinloadingfordualtargetedtumordrugdelivery AT guol immobilizedtransferrinfe3o4sio2nanoparticlewithhighdoxorubicinloadingfordualtargetedtumordrugdelivery
_version_	1718400348380463104

Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery

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