Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in prolonged survival in animal models.

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Autores principales:	Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8
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spelling	oai:doaj.org-article:4116e5b63fd745dd8d4fa955d44571c82021-12-02T13:30:20ZDual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas10.1038/s41467-021-20896-z2041-1723https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20896-zhttps://doaj.org/toc/2041-1723Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in prolonged survival in animal models.Aaminah KhanLaura D. GambleDannielle H. UptonCaitlin UngDenise M. T. YuAnahid EhtedaRuby PandherChelsea MayohSteven HébertNada JabadoClaudia L. KleinmanMark R. BurnsMurray D. NorrisMichelle HaberMaria TsoliDavid S. ZieglerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaminah Khan Laura D. Gamble Dannielle H. Upton Caitlin Ung Denise M. T. Yu Anahid Ehteda Ruby Pandher Chelsea Mayoh Steven Hébert Nada Jabado Claudia L. Kleinman Mark R. Burns Murray D. Norris Michelle Haber Maria Tsoli David S. Ziegler Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
description	Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in prolonged survival in animal models.
format	article
author	Aaminah Khan Laura D. Gamble Dannielle H. Upton Caitlin Ung Denise M. T. Yu Anahid Ehteda Ruby Pandher Chelsea Mayoh Steven Hébert Nada Jabado Claudia L. Kleinman Mark R. Burns Murray D. Norris Michelle Haber Maria Tsoli David S. Ziegler
author_facet	Aaminah Khan Laura D. Gamble Dannielle H. Upton Caitlin Ung Denise M. T. Yu Anahid Ehteda Ruby Pandher Chelsea Mayoh Steven Hébert Nada Jabado Claudia L. Kleinman Mark R. Burns Murray D. Norris Michelle Haber Maria Tsoli David S. Ziegler
author_sort	Aaminah Khan
title	Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
title_short	Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
title_full	Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
title_fullStr	Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
title_full_unstemmed	Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
title_sort	dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8
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Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

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