Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent

Abstract Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature an...

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Autores principales:	Vu Hoang Minh Doan, Van Tu Nguyen, Sudip Mondal, Thi Mai Thien Vo, Cao Duong Ly, Dinh Dat Vu, Gebremedhin Yonatan Ataklti, Sumin Park, Jaeyeop Choi, Junghwan Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/411c7268f5d54dff86d62e806f06e1cd
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spelling	oai:doaj.org-article:411c7268f5d54dff86d62e806f06e1cd2021-12-02T17:06:25ZFluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent10.1038/s41598-021-95660-w2045-2322https://doaj.org/article/411c7268f5d54dff86d62e806f06e1cd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95660-whttps://doaj.org/toc/2045-2322Abstract Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mutually supportive characteristic in terms of spatial resolution, penetration depth, imaging sensitivity, and speed. In this present study, we synthesized IR783 conjugated chitosan–polypyrrole nanocomposites (IR-CS–PPy NCs) as a theragnostic agent used for FL/PA dual-modal imaging. A customized FL and photoacoustic imaging system was constructed to perform required imaging experiments and create high-contrast images. The proposed nanocomposites were confirmed to have great biosafety, essentially a near-infrared (NIR) absorbance property with enhanced photostability. The in vitro photothermal results indicate the high-efficiency MDA-MB-231 breast cancer cell ablation ability of IR-CS–PPy NCs under 808 nm NIR laser irradiation. The in vivo PTT study revealed the complete destruction of the tumor tissues with IR-CS–PPy NCs without further recurrence. The in vitro and in vivo results suggest that the demonstrated nanocomposites, together with the proposed imaging systems could be an effective theragnostic agent for imaging-guided cancer treatment.Vu Hoang Minh DoanVan Tu NguyenSudip MondalThi Mai Thien VoCao Duong LyDinh Dat VuGebremedhin Yonatan AtakltiSumin ParkJaeyeop ChoiJunghwan OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vu Hoang Minh Doan Van Tu Nguyen Sudip Mondal Thi Mai Thien Vo Cao Duong Ly Dinh Dat Vu Gebremedhin Yonatan Ataklti Sumin Park Jaeyeop Choi Junghwan Oh Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
description	Abstract Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mutually supportive characteristic in terms of spatial resolution, penetration depth, imaging sensitivity, and speed. In this present study, we synthesized IR783 conjugated chitosan–polypyrrole nanocomposites (IR-CS–PPy NCs) as a theragnostic agent used for FL/PA dual-modal imaging. A customized FL and photoacoustic imaging system was constructed to perform required imaging experiments and create high-contrast images. The proposed nanocomposites were confirmed to have great biosafety, essentially a near-infrared (NIR) absorbance property with enhanced photostability. The in vitro photothermal results indicate the high-efficiency MDA-MB-231 breast cancer cell ablation ability of IR-CS–PPy NCs under 808 nm NIR laser irradiation. The in vivo PTT study revealed the complete destruction of the tumor tissues with IR-CS–PPy NCs without further recurrence. The in vitro and in vivo results suggest that the demonstrated nanocomposites, together with the proposed imaging systems could be an effective theragnostic agent for imaging-guided cancer treatment.
format	article
author	Vu Hoang Minh Doan Van Tu Nguyen Sudip Mondal Thi Mai Thien Vo Cao Duong Ly Dinh Dat Vu Gebremedhin Yonatan Ataklti Sumin Park Jaeyeop Choi Junghwan Oh
author_facet	Vu Hoang Minh Doan Van Tu Nguyen Sudip Mondal Thi Mai Thien Vo Cao Duong Ly Dinh Dat Vu Gebremedhin Yonatan Ataklti Sumin Park Jaeyeop Choi Junghwan Oh
author_sort	Vu Hoang Minh Doan
title	Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
title_short	Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
title_full	Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
title_fullStr	Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
title_full_unstemmed	Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
title_sort	fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/411c7268f5d54dff86d62e806f06e1cd
work_keys_str_mv	AT vuhoangminhdoan fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT vantunguyen fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT sudipmondal fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT thimaithienvo fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT caoduongly fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT dinhdatvu fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT gebremedhinyonatanataklti fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT suminpark fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT jaeyeopchoi fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent AT junghwanoh fluorescencephotoacousticimagingguidednanomaterialsforhighlyefficientcancertheragnosticagent
_version_	1718381607542325248

Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent

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