Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits

The study was aimed to screen the presence of phytoconstituents and determine distinct in vitro medicinal traits of aqueous and ethanolic extracts of Solanum virginianum dried fruits. Aqueous and ethanolic extract showed total phenolic content of 207.5 ± 0.16 and 268.4 ± 0.42 GAE/mg, respectively. L...

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Autores principales:	K. Saraswathi, R. Bharkavi, Ameer Khusro, C. Sivaraj, P. Arumugam, Saad Alghamdi, Anas S. Dablool, Mazen Almehmadi, Azzah M. Bannunah, Muhammad Umar Khayam Sahibzada
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Fruit extracts GC–MS Medicinal properties Solanum virginianum Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/41212122483248a09213ca12b5985ff2
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spelling	oai:doaj.org-article:41212122483248a09213ca12b5985ff22021-11-20T04:57:59ZAssessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits1878-535210.1016/j.arabjc.2021.103442https://doaj.org/article/41212122483248a09213ca12b5985ff22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221004573https://doaj.org/toc/1878-5352The study was aimed to screen the presence of phytoconstituents and determine distinct in vitro medicinal traits of aqueous and ethanolic extracts of Solanum virginianum dried fruits. Aqueous and ethanolic extract showed total phenolic content of 207.5 ± 0.16 and 268.4 ± 0.42 GAE/mg, respectively. Likewise, total flavonoid content of 50.12 ± 0.39 and 192.88 ± 0.27 QE/mg was estimated for the aqueous and ethanolic extract, respectively. In vitro antibacterial, antioxidant, α-amylase inhibition, anti-inflammatory, and anticancer attributes of extracts were assessed using standard protocols. The antibacterial traits of both the extracts were assessed against certain pathogenic bacteria which exhibited maximum zone of inhibition of 22.3 ± 0.6 mm against Staphylococcus aureus. Antioxidant tests showed not only significant scavenging of DPPH, superoxide, hydroxyl, and ABTS●+ radicals but also estimated ferric reducing power and phosphomolybdenum reduction activities of extracts in a concentration dependent manner. The aqueous extract (54.12 ± 0.44–86.80 ± 0.27%) depicted higher rate of α-amylase inhibition than ethanolic extract (23.07 ± 0.47–81.61 ± 0.43%) at distinct concentrations. Similarly, the aqueous extract protected the haemolysis (46.19 ± 0.14–66.21 ± 0.17%) effectively as compared to the ethanolic extract (12.67 ± 0.19–38.03 ± 0.41%). The aqueous and ethanolic extract showed cytotoxicity against HepG2 cell lines in the range of 32.23 ± 0.34–54.82 ± 0.26% and 49.25 ± 0.38–73.2 ± 0.3%, respectively. Additionally, the GC–MS analysis confirmed the availability of total 15 predominant bioactive constituents in both extracts. Findings of this context indicated pronounced applications of S. virginianum fruits as future therapeutic.K. SaraswathiR. BharkaviAmeer KhusroC. SivarajP. ArumugamSaad AlghamdiAnas S. DabloolMazen AlmehmadiAzzah M. BannunahMuhammad Umar Khayam SahibzadaElsevierarticleFruit extractsGC–MSMedicinal propertiesSolanum virginianumChemistryQD1-999ENArabian Journal of Chemistry, Vol 14, Iss 12, Pp 103442- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fruit extracts GC–MS Medicinal properties Solanum virginianum Chemistry QD1-999
spellingShingle	Fruit extracts GC–MS Medicinal properties Solanum virginianum Chemistry QD1-999 K. Saraswathi R. Bharkavi Ameer Khusro C. Sivaraj P. Arumugam Saad Alghamdi Anas S. Dablool Mazen Almehmadi Azzah M. Bannunah Muhammad Umar Khayam Sahibzada Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits
description	The study was aimed to screen the presence of phytoconstituents and determine distinct in vitro medicinal traits of aqueous and ethanolic extracts of Solanum virginianum dried fruits. Aqueous and ethanolic extract showed total phenolic content of 207.5 ± 0.16 and 268.4 ± 0.42 GAE/mg, respectively. Likewise, total flavonoid content of 50.12 ± 0.39 and 192.88 ± 0.27 QE/mg was estimated for the aqueous and ethanolic extract, respectively. In vitro antibacterial, antioxidant, α-amylase inhibition, anti-inflammatory, and anticancer attributes of extracts were assessed using standard protocols. The antibacterial traits of both the extracts were assessed against certain pathogenic bacteria which exhibited maximum zone of inhibition of 22.3 ± 0.6 mm against Staphylococcus aureus. Antioxidant tests showed not only significant scavenging of DPPH, superoxide, hydroxyl, and ABTS●+ radicals but also estimated ferric reducing power and phosphomolybdenum reduction activities of extracts in a concentration dependent manner. The aqueous extract (54.12 ± 0.44–86.80 ± 0.27%) depicted higher rate of α-amylase inhibition than ethanolic extract (23.07 ± 0.47–81.61 ± 0.43%) at distinct concentrations. Similarly, the aqueous extract protected the haemolysis (46.19 ± 0.14–66.21 ± 0.17%) effectively as compared to the ethanolic extract (12.67 ± 0.19–38.03 ± 0.41%). The aqueous and ethanolic extract showed cytotoxicity against HepG2 cell lines in the range of 32.23 ± 0.34–54.82 ± 0.26% and 49.25 ± 0.38–73.2 ± 0.3%, respectively. Additionally, the GC–MS analysis confirmed the availability of total 15 predominant bioactive constituents in both extracts. Findings of this context indicated pronounced applications of S. virginianum fruits as future therapeutic.
format	article
author	K. Saraswathi R. Bharkavi Ameer Khusro C. Sivaraj P. Arumugam Saad Alghamdi Anas S. Dablool Mazen Almehmadi Azzah M. Bannunah Muhammad Umar Khayam Sahibzada
author_facet	K. Saraswathi R. Bharkavi Ameer Khusro C. Sivaraj P. Arumugam Saad Alghamdi Anas S. Dablool Mazen Almehmadi Azzah M. Bannunah Muhammad Umar Khayam Sahibzada
author_sort	K. Saraswathi
title	Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits
title_short	Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits
title_full	Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits
title_fullStr	Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits
title_full_unstemmed	Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits
title_sort	assessment on in vitro medicinal properties and chemical composition analysis of solanum virginianum dried fruits
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/41212122483248a09213ca12b5985ff2
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Assessment on in vitro medicinal properties and chemical composition analysis of Solanum virginianum dried fruits

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