Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial

Background: Adequate fibre consumption is associated with reduced risk of metabolic syndrome and cardiovascular disease. This study examined the effects of supplementation with PolyGlycopleX® (PGX®), a complex of 3 polysaccharides (fibre product), on blood pressure, arterial stiffness and C-reactive...

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Autores principales:	Sebely Pal, Monica Jane, Suleen Ho, Roland J. Gahler, Simon Wood
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Blood pressure C-reactive protein Fibre Inflammation Obesity Overweight Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/4121410e7d4448df93c12006fe6033fe
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spelling	oai:doaj.org-article:4121410e7d4448df93c12006fe6033fe2021-11-04T04:39:40ZEffect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial2666-149710.1016/j.hnm.2021.200132https://doaj.org/article/4121410e7d4448df93c12006fe6033fe2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666149721000141https://doaj.org/toc/2666-1497Background: Adequate fibre consumption is associated with reduced risk of metabolic syndrome and cardiovascular disease. This study examined the effects of supplementation with PolyGlycopleX® (PGX®), a complex of 3 polysaccharides (fibre product), on blood pressure, arterial stiffness and C-reactive protein in overweight and obese participants. Methods: In this double-blind 12-month trial, participants were randomised into three groups: control (CTR; rice flour); PGX or a proprietary psyllium product (PSY). Participants added the 5 g supplements to their habitual diet and lifestyle, three times daily before meals. Results: Between-groups analysis shows that systolic blood pressure was significantly lower in the PGX group at 3 months compared to CTR; stiffness index in the PGX group was significantly lower at 3 months compared to CTR. Within-group analysis shows systolic and diastolic blood pressure, as well as arterial stiffness, to be significantly lower in the PGX group at 3 months compared to baseline. Conclusions: While fibre supplementation may be an effective strategy to reduce chronic disease risk factors without the need for other dietary modifications, the present study suggests that more clinical trials with PGX are needed to clarify whether supplementing the with this product will reduce inflammation and improve vascular health in overweight and obese individuals.Trial registration: Australian New Zealand Clinical Trial Registry: ACTRN12611000415909. Registered 20 April 2011.Sebely PalMonica JaneSuleen HoRoland J. GahlerSimon WoodElsevierarticleBlood pressureC-reactive proteinFibreInflammationObesityOverweightNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENHuman Nutrition & Metabolism, Vol 26, Iss , Pp 200132- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Blood pressure C-reactive protein Fibre Inflammation Obesity Overweight Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Blood pressure C-reactive protein Fibre Inflammation Obesity Overweight Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Sebely Pal Monica Jane Suleen Ho Roland J. Gahler Simon Wood Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
description	Background: Adequate fibre consumption is associated with reduced risk of metabolic syndrome and cardiovascular disease. This study examined the effects of supplementation with PolyGlycopleX® (PGX®), a complex of 3 polysaccharides (fibre product), on blood pressure, arterial stiffness and C-reactive protein in overweight and obese participants. Methods: In this double-blind 12-month trial, participants were randomised into three groups: control (CTR; rice flour); PGX or a proprietary psyllium product (PSY). Participants added the 5 g supplements to their habitual diet and lifestyle, three times daily before meals. Results: Between-groups analysis shows that systolic blood pressure was significantly lower in the PGX group at 3 months compared to CTR; stiffness index in the PGX group was significantly lower at 3 months compared to CTR. Within-group analysis shows systolic and diastolic blood pressure, as well as arterial stiffness, to be significantly lower in the PGX group at 3 months compared to baseline. Conclusions: While fibre supplementation may be an effective strategy to reduce chronic disease risk factors without the need for other dietary modifications, the present study suggests that more clinical trials with PGX are needed to clarify whether supplementing the with this product will reduce inflammation and improve vascular health in overweight and obese individuals.Trial registration: Australian New Zealand Clinical Trial Registry: ACTRN12611000415909. Registered 20 April 2011.
format	article
author	Sebely Pal Monica Jane Suleen Ho Roland J. Gahler Simon Wood
author_facet	Sebely Pal Monica Jane Suleen Ho Roland J. Gahler Simon Wood
author_sort	Sebely Pal
title	Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
title_short	Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
title_full	Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
title_fullStr	Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
title_full_unstemmed	Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
title_sort	effect of two different fibre supplements on blood pressure, arterial stiffness and c-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4121410e7d4448df93c12006fe6033fe
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Effect of two different fibre supplements on blood pressure, arterial stiffness and C-reactive protein in adults with overweight and obesity consumed over 12 months, in a randomised controlled trial

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