Metavinculin modulates force transduction in cell adhesion sites

Metavinculin modulates force transduction in cell adhesion sites

Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop a mouse model to demonstrate that the presenc...

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Autores principales: Verena Kanoldt, Carleen Kluger, Christiane Barz, Anna-Lena Schweizer, Deepak Ramanujam, Lukas Windgasse, Stefan Engelhardt, Anna Chrostek-Grashoff, Carsten Grashoff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/41224288e6bf406cae4c8c93563209a2
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spelling oai:doaj.org-article:41224288e6bf406cae4c8c93563209a22021-12-02T14:16:32ZMetavinculin modulates force transduction in cell adhesion sites10.1038/s41467-020-20125-z2041-1723https://doaj.org/article/41224288e6bf406cae4c8c93563209a22020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20125-zhttps://doaj.org/toc/2041-1723Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop a mouse model to demonstrate that the presence of metavinculin is not as critical for heart muscle function as previously thought.Verena KanoldtCarleen KlugerChristiane BarzAnna-Lena SchweizerDeepak RamanujamLukas WindgasseStefan EngelhardtAnna Chrostek-GrashoffCarsten GrashoffNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Verena Kanoldt
Carleen Kluger
Christiane Barz
Anna-Lena Schweizer
Deepak Ramanujam
Lukas Windgasse
Stefan Engelhardt
Anna Chrostek-Grashoff
Carsten Grashoff
Metavinculin modulates force transduction in cell adhesion sites
description Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop a mouse model to demonstrate that the presence of metavinculin is not as critical for heart muscle function as previously thought.
format article
author Verena Kanoldt
Carleen Kluger
Christiane Barz
Anna-Lena Schweizer
Deepak Ramanujam
Lukas Windgasse
Stefan Engelhardt
Anna Chrostek-Grashoff
Carsten Grashoff
author_facet Verena Kanoldt
Carleen Kluger
Christiane Barz
Anna-Lena Schweizer
Deepak Ramanujam
Lukas Windgasse
Stefan Engelhardt
Anna Chrostek-Grashoff
Carsten Grashoff
author_sort Verena Kanoldt
title Metavinculin modulates force transduction in cell adhesion sites
title_short Metavinculin modulates force transduction in cell adhesion sites
title_full Metavinculin modulates force transduction in cell adhesion sites
title_fullStr Metavinculin modulates force transduction in cell adhesion sites
title_full_unstemmed Metavinculin modulates force transduction in cell adhesion sites
title_sort metavinculin modulates force transduction in cell adhesion sites
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/41224288e6bf406cae4c8c93563209a2
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AT annalenaschweizer metavinculinmodulatesforcetransductionincelladhesionsites
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AT annachrostekgrashoff metavinculinmodulatesforcetransductionincelladhesionsites
AT carstengrashoff metavinculinmodulatesforcetransductionincelladhesionsites
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