Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease

Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease

Abstract Evidence suggests that synapses are affected first in Parkinson’s disease (PD). Here, we tested the claim that pathological accumulation of α-synuclein, and subsequent synaptic disruption, occur in absence of dopaminergic neuron loss in PD. We determined early synaptic changes in rats that...

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Autores principales: Jenny-Ann Phan, Kathrine Stokholm, Justyna Zareba-Paslawska, Steen Jakobsen, Kim Vang, Albert Gjedde, Anne M. Landau, Marina Romero-Ramos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/41225ca7cc2e4bf497ecd7a63170b7db
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