Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic

ABSTRACT Proponents of the use of gain-of-function (GOF) experiments with pathogens with pandemic potential (PPP) have argued that such experiments are necessary because they reveal important facets of pathogenesis and can be performed safely. Opponents of GOF experiments with PPP have argued that t...

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Autores principales:	Michael J. Imperiale, Arturo Casadevall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	biosafety bioterrorism policy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/412fd678093844928afa841a387b4f4a
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spelling	oai:doaj.org-article:412fd678093844928afa841a387b4f4a2021-11-15T15:56:45ZRethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic10.1128/mBio.01868-202150-7511https://doaj.org/article/412fd678093844928afa841a387b4f4a2020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01868-20https://doaj.org/toc/2150-7511ABSTRACT Proponents of the use of gain-of-function (GOF) experiments with pathogens with pandemic potential (PPP) have argued that such experiments are necessary because they reveal important facets of pathogenesis and can be performed safely. Opponents of GOF experiments with PPP have argued that the risks outweigh the knowledge gained. The COVID-19 pandemic demonstrates the vulnerability of human societies to a new PPP, while also validating some arguments of both camps, questioning others, and suggesting the need to rethink how we approach this class of experiments.Michael J. ImperialeArturo CasadevallAmerican Society for MicrobiologyarticlebiosafetybioterrorismpolicyMicrobiologyQR1-502ENmBio, Vol 11, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	biosafety bioterrorism policy Microbiology QR1-502
spellingShingle	biosafety bioterrorism policy Microbiology QR1-502 Michael J. Imperiale Arturo Casadevall Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic
description	ABSTRACT Proponents of the use of gain-of-function (GOF) experiments with pathogens with pandemic potential (PPP) have argued that such experiments are necessary because they reveal important facets of pathogenesis and can be performed safely. Opponents of GOF experiments with PPP have argued that the risks outweigh the knowledge gained. The COVID-19 pandemic demonstrates the vulnerability of human societies to a new PPP, while also validating some arguments of both camps, questioning others, and suggesting the need to rethink how we approach this class of experiments.
format	article
author	Michael J. Imperiale Arturo Casadevall
author_facet	Michael J. Imperiale Arturo Casadevall
author_sort	Michael J. Imperiale
title	Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic
title_short	Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic
title_full	Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic
title_fullStr	Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic
title_full_unstemmed	Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic
title_sort	rethinking gain-of-function experiments in the context of the covid-19 pandemic
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/412fd678093844928afa841a387b4f4a
work_keys_str_mv	AT michaeljimperiale rethinkinggainoffunctionexperimentsinthecontextofthecovid19pandemic AT arturocasadevall rethinkinggainoffunctionexperimentsinthecontextofthecovid19pandemic
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Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic

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