Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.

Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.

<h4>Background</h4>Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been invest...

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Main Authors: Mahban Irandoust, Julian Alvarez Zarate, Isabelle Hubeek, Ellen M van Beek, Karin Schornagel, Aart J F Broekhuizen, Mercan Akyuz, Arjan A van de Loosdrecht, Ruud Delwel, Peter J Valk, Edwin Sonneveld, Pamela Kearns, Ursula Creutzig, Dirk Reinhardt, Eveline S J M de Bont, Eva A Coenen, Marry M van den Heuvel-Eibrink, C Michel Zwaan, Gertjan J L Kaspers, Jacqueline Cloos, Timo K van den Berg
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/4130b2e000fb4e6db767bbaff246bd5c
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https://doaj.org/article/4130b2e000fb4e6db767bbaff246bd5c

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