Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC

Abstract Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor...

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Autores principales:	Thomas Karsten Kilvaer, Mehrdad Rakaee, Turid Hellevik, Jørg Vik, Luigi De Petris, Tom Donnem, Carina Strell, Arne Ostman, Lill-Tove Rasmussen Busund, Inigo Martinez-Zubiaurre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41323426fa774eeb847449f5998643f9
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spelling	oai:doaj.org-article:41323426fa774eeb847449f5998643f92021-12-02T15:09:33ZDifferential prognostic impact of platelet-derived growth factor receptor expression in NSCLC10.1038/s41598-019-46510-32045-2322https://doaj.org/article/41323426fa774eeb847449f5998643f92019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46510-3https://doaj.org/toc/2045-2322Abstract Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) were constructed (Norwegian cohort). Immunohistochemistry (IHC) was used to evaluate the expression of PDGFRα and -β in stromal cells and to explore their impact on patient survival. Results were validated in a non-related cohort consisting of TMAs of 367 stage I (A and B) NSCLC patients (Swedish cohort). High stromal PDGFRα expression was an independent predictor of increased survival in the overall populations and SCC (squamous cell carcinoma) subgroups of both investigated cohorts. PDGFRβ was an independent predictor of poor survival in the overall Norwegian cohort and an independent predictor of increased survival in the ADC (adenocarcinoma) subgroup of the Swedish cohort. Tumors displaying the combination PDGFRα-low/PDGFRβ-high exhibited inferior survival according to increasing stage in the Norwegian cohort. This study confirms that high stromal expression of PDGFRα is a predictor of increased survival in NSCLC. Further exploration of the prognostic impact of PDGFRβ and the relationship between PDGFRα and -β is warranted.Thomas Karsten KilvaerMehrdad RakaeeTurid HellevikJørg VikLuigi De PetrisTom DonnemCarina StrellArne OstmanLill-Tove Rasmussen BusundInigo Martinez-ZubiaurreNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas Karsten Kilvaer Mehrdad Rakaee Turid Hellevik Jørg Vik Luigi De Petris Tom Donnem Carina Strell Arne Ostman Lill-Tove Rasmussen Busund Inigo Martinez-Zubiaurre Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
description	Abstract Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) were constructed (Norwegian cohort). Immunohistochemistry (IHC) was used to evaluate the expression of PDGFRα and -β in stromal cells and to explore their impact on patient survival. Results were validated in a non-related cohort consisting of TMAs of 367 stage I (A and B) NSCLC patients (Swedish cohort). High stromal PDGFRα expression was an independent predictor of increased survival in the overall populations and SCC (squamous cell carcinoma) subgroups of both investigated cohorts. PDGFRβ was an independent predictor of poor survival in the overall Norwegian cohort and an independent predictor of increased survival in the ADC (adenocarcinoma) subgroup of the Swedish cohort. Tumors displaying the combination PDGFRα-low/PDGFRβ-high exhibited inferior survival according to increasing stage in the Norwegian cohort. This study confirms that high stromal expression of PDGFRα is a predictor of increased survival in NSCLC. Further exploration of the prognostic impact of PDGFRβ and the relationship between PDGFRα and -β is warranted.
format	article
author	Thomas Karsten Kilvaer Mehrdad Rakaee Turid Hellevik Jørg Vik Luigi De Petris Tom Donnem Carina Strell Arne Ostman Lill-Tove Rasmussen Busund Inigo Martinez-Zubiaurre
author_facet	Thomas Karsten Kilvaer Mehrdad Rakaee Turid Hellevik Jørg Vik Luigi De Petris Tom Donnem Carina Strell Arne Ostman Lill-Tove Rasmussen Busund Inigo Martinez-Zubiaurre
author_sort	Thomas Karsten Kilvaer
title	Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
title_short	Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
title_full	Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
title_fullStr	Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
title_full_unstemmed	Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
title_sort	differential prognostic impact of platelet-derived growth factor receptor expression in nsclc
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/41323426fa774eeb847449f5998643f9
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Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC

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