Waking and sleeping following water deprivation in the rat.

Wake-sleep (W-S) states are affected by thermoregulation. In particular, REM sleep (REMS) is reduced in homeotherms under a thermal load, due to an impairment of hypothalamic regulation of body temperature. The aim of this work was to assess whether osmoregulation, which is regulated at a hypothalam...

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Autores principales:	Davide Martelli, Marco Luppi, Matteo Cerri, Domenico Tupone, Emanuele Perez, Giovanni Zamboni, Roberto Amici
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41323ce4d0914cf49725d9ebdf2a2f31
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spelling	oai:doaj.org-article:41323ce4d0914cf49725d9ebdf2a2f312021-11-18T07:04:15ZWaking and sleeping following water deprivation in the rat.1932-620310.1371/journal.pone.0046116https://doaj.org/article/41323ce4d0914cf49725d9ebdf2a2f312012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029406/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Wake-sleep (W-S) states are affected by thermoregulation. In particular, REM sleep (REMS) is reduced in homeotherms under a thermal load, due to an impairment of hypothalamic regulation of body temperature. The aim of this work was to assess whether osmoregulation, which is regulated at a hypothalamic level, but, unlike thermoregulation, is maintained across the different W-S states, could influence W-S occurrence. Sprague-Dawley rats, kept at an ambient temperature of 24°C and under a 12 h∶12 h light-dark cycle, were exposed to a prolonged osmotic challenge of three days of water deprivation (WD) and two days of recovery in which free access to water was restored. Two sets of parameters were determined in order to assess: i) the maintenance of osmotic homeostasis (water and food consumption; changes in body weight and fluid composition); ii) the effects of the osmotic challenge on behavioral states (hypothalamic temperature (Thy), motor activity, and W-S states). The first set of parameters changed in WD as expected and control levels were restored on the second day of recovery, with the exception of urinary Ca(++) that almost disappeared in WD, and increased to a high level in recovery. As far as the second set is concerned, WD was characterized by the maintenance of the daily oscillation of Thy and by a decrease in activity during the dark periods. Changes in W-S states were small and mainly confined to the dark period: i) REMS slightly decreased at the end of WD and increased in recovery; ii) non-REM sleep (NREMS) increased in both WD and recovery, but EEG delta power, a sign of NREMS intensity, decreased in WD and increased in recovery. Our data suggest that osmoregulation interferes with the regulation of W-S states to a much lesser extent than thermoregulation.Davide MartelliMarco LuppiMatteo CerriDomenico TuponeEmanuele PerezGiovanni ZamboniRoberto AmiciPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46116 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Davide Martelli Marco Luppi Matteo Cerri Domenico Tupone Emanuele Perez Giovanni Zamboni Roberto Amici Waking and sleeping following water deprivation in the rat.
description	Wake-sleep (W-S) states are affected by thermoregulation. In particular, REM sleep (REMS) is reduced in homeotherms under a thermal load, due to an impairment of hypothalamic regulation of body temperature. The aim of this work was to assess whether osmoregulation, which is regulated at a hypothalamic level, but, unlike thermoregulation, is maintained across the different W-S states, could influence W-S occurrence. Sprague-Dawley rats, kept at an ambient temperature of 24°C and under a 12 h∶12 h light-dark cycle, were exposed to a prolonged osmotic challenge of three days of water deprivation (WD) and two days of recovery in which free access to water was restored. Two sets of parameters were determined in order to assess: i) the maintenance of osmotic homeostasis (water and food consumption; changes in body weight and fluid composition); ii) the effects of the osmotic challenge on behavioral states (hypothalamic temperature (Thy), motor activity, and W-S states). The first set of parameters changed in WD as expected and control levels were restored on the second day of recovery, with the exception of urinary Ca(++) that almost disappeared in WD, and increased to a high level in recovery. As far as the second set is concerned, WD was characterized by the maintenance of the daily oscillation of Thy and by a decrease in activity during the dark periods. Changes in W-S states were small and mainly confined to the dark period: i) REMS slightly decreased at the end of WD and increased in recovery; ii) non-REM sleep (NREMS) increased in both WD and recovery, but EEG delta power, a sign of NREMS intensity, decreased in WD and increased in recovery. Our data suggest that osmoregulation interferes with the regulation of W-S states to a much lesser extent than thermoregulation.
format	article
author	Davide Martelli Marco Luppi Matteo Cerri Domenico Tupone Emanuele Perez Giovanni Zamboni Roberto Amici
author_facet	Davide Martelli Marco Luppi Matteo Cerri Domenico Tupone Emanuele Perez Giovanni Zamboni Roberto Amici
author_sort	Davide Martelli
title	Waking and sleeping following water deprivation in the rat.
title_short	Waking and sleeping following water deprivation in the rat.
title_full	Waking and sleeping following water deprivation in the rat.
title_fullStr	Waking and sleeping following water deprivation in the rat.
title_full_unstemmed	Waking and sleeping following water deprivation in the rat.
title_sort	waking and sleeping following water deprivation in the rat.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/41323ce4d0914cf49725d9ebdf2a2f31
work_keys_str_mv	AT davidemartelli wakingandsleepingfollowingwaterdeprivationintherat AT marcoluppi wakingandsleepingfollowingwaterdeprivationintherat AT matteocerri wakingandsleepingfollowingwaterdeprivationintherat AT domenicotupone wakingandsleepingfollowingwaterdeprivationintherat AT emanueleperez wakingandsleepingfollowingwaterdeprivationintherat AT giovannizamboni wakingandsleepingfollowingwaterdeprivationintherat AT robertoamici wakingandsleepingfollowingwaterdeprivationintherat
_version_	1718423972732731392

Waking and sleeping following water deprivation in the rat.

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