Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults

Objective: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Previous studies have indicated that clustering of major CVD risk factors is common. We aimed to explore the association of clustering of CVD risk factors with arterial stiffness in adults. Methods: A...

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Autores principales:	Xiang-Lei Kong, Xiao-Jing Ma, Cheng-Yin Zhang, Dong-Mei Xu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4132d17f28eb4946acae908a559a97e5
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spelling	oai:doaj.org-article:4132d17f28eb4946acae908a559a97e52021-12-02T13:22:08ZClustering of major cardiovascular risk factors is associated with arterial stiffness in adults2095-882X10.1016/j.cdtm.2018.02.005https://doaj.org/article/4132d17f28eb4946acae908a559a97e52018-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X17300981https://doaj.org/toc/2095-882XObjective: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Previous studies have indicated that clustering of major CVD risk factors is common. We aimed to explore the association of clustering of CVD risk factors with arterial stiffness in adults. Methods: A total of 9984 adults were enrolled. We investigated clustering of four major CVD risk factors (defined as two or more of the following: hypertension, diabetes, dyslipidemia, and high body mass index) and their association with arterial stiffness. Arterial stiffness was evaluated using the carotid-femoral pulse wave velocity (cfPWV). Results: In the study group (52.2% men, the mean age was 55.4 ± 10.5 years; only 11.9% of participants were free of any pre-defined CVD risk factors and 61.8% of participants had clustering of CVD risk factors. The cfPWV was significantly higher in the clustered risk factors group than in the no risk factor or the single risk factor groups (16.1 ± 3.1, 13.4 ± 2.2, and 14.3 ± 2.6 m/s, respectively; P < 0.001). Multiple linear regression analysis revealed that age, gender, clustering of CVD risk factors, serum uric acid, and decreased renal function positively correlated with cfPWV. For a categorical outcome, the highest cfPWV quartile (cfPWV ≥ 16.9 m/s) was compared with the lower three quartiles. After adjusting for potential confounders, clustering of CVD risk factors significantly correlated with increased cfPWV compared with that in the no risk factor group, with an odds ratio of 5.76 (95% confidence interval: 4.46–7.44). Conclusions: Clustering of CVD risk factors significantly correlated with arterial stiffness; this confirms the importance of lifestyle modification to reduce the burden of CVD. Keywords: Cardiovascular disease, Cluster, Arterial stiffness, Pulse wave velocityXiang-Lei KongXiao-Jing MaCheng-Yin ZhangDong-Mei XuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 4, Pp 254-259 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiang-Lei Kong Xiao-Jing Ma Cheng-Yin Zhang Dong-Mei Xu Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
description	Objective: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide. Previous studies have indicated that clustering of major CVD risk factors is common. We aimed to explore the association of clustering of CVD risk factors with arterial stiffness in adults. Methods: A total of 9984 adults were enrolled. We investigated clustering of four major CVD risk factors (defined as two or more of the following: hypertension, diabetes, dyslipidemia, and high body mass index) and their association with arterial stiffness. Arterial stiffness was evaluated using the carotid-femoral pulse wave velocity (cfPWV). Results: In the study group (52.2% men, the mean age was 55.4 ± 10.5 years; only 11.9% of participants were free of any pre-defined CVD risk factors and 61.8% of participants had clustering of CVD risk factors. The cfPWV was significantly higher in the clustered risk factors group than in the no risk factor or the single risk factor groups (16.1 ± 3.1, 13.4 ± 2.2, and 14.3 ± 2.6 m/s, respectively; P < 0.001). Multiple linear regression analysis revealed that age, gender, clustering of CVD risk factors, serum uric acid, and decreased renal function positively correlated with cfPWV. For a categorical outcome, the highest cfPWV quartile (cfPWV ≥ 16.9 m/s) was compared with the lower three quartiles. After adjusting for potential confounders, clustering of CVD risk factors significantly correlated with increased cfPWV compared with that in the no risk factor group, with an odds ratio of 5.76 (95% confidence interval: 4.46–7.44). Conclusions: Clustering of CVD risk factors significantly correlated with arterial stiffness; this confirms the importance of lifestyle modification to reduce the burden of CVD. Keywords: Cardiovascular disease, Cluster, Arterial stiffness, Pulse wave velocity
format	article
author	Xiang-Lei Kong Xiao-Jing Ma Cheng-Yin Zhang Dong-Mei Xu
author_facet	Xiang-Lei Kong Xiao-Jing Ma Cheng-Yin Zhang Dong-Mei Xu
author_sort	Xiang-Lei Kong
title	Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
title_short	Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
title_full	Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
title_fullStr	Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
title_full_unstemmed	Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
title_sort	clustering of major cardiovascular risk factors is associated with arterial stiffness in adults
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/4132d17f28eb4946acae908a559a97e5
work_keys_str_mv	AT xiangleikong clusteringofmajorcardiovascularriskfactorsisassociatedwitharterialstiffnessinadults AT xiaojingma clusteringofmajorcardiovascularriskfactorsisassociatedwitharterialstiffnessinadults AT chengyinzhang clusteringofmajorcardiovascularriskfactorsisassociatedwitharterialstiffnessinadults AT dongmeixu clusteringofmajorcardiovascularriskfactorsisassociatedwitharterialstiffnessinadults
_version_	1718393145349111808

Clustering of major cardiovascular risk factors is associated with arterial stiffness in adults

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