Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro

Abstract The application of stannous ions in combination with fluoride (F/Sn) is one of the central strategies in reducing erosive tooth wear. F/Sn efficacy can be enhanced by adding chitosan, a positively charged biopolymer. For patients with low saliva flow, this efficacy, however, is not sufficie...

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Autores principales:	Benedikt Luka, Vivien Arbter, Kathrin Sander, Andrea Duerrschnabel, Nadine Schlueter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41342cb452b2427099cdc72b2d64abda
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spelling	oai:doaj.org-article:41342cb452b2427099cdc72b2d64abda2021-12-02T11:37:26ZImpact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro10.1038/s41598-021-84791-92045-2322https://doaj.org/article/41342cb452b2427099cdc72b2d64abda2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84791-9https://doaj.org/toc/2045-2322Abstract The application of stannous ions in combination with fluoride (F/Sn) is one of the central strategies in reducing erosive tooth wear. F/Sn efficacy can be enhanced by adding chitosan, a positively charged biopolymer. For patients with low saliva flow, this efficacy, however, is not sufficient, making further improvement desirable. This could be achieved by combining chitosan with other molecules like mucin, which together might form multilayers. This in-vitro study aimed to investigate the effect of chitosan, mucin, F/Sn and combinations thereof on enamel erosion and erosion-abrasion. Human enamel samples (n = 448, 28 groups) were cyclically eroded or eroded-abraded (10 days; 6 × 2 min erosion and 2 × 15 s/200 g abrasion per day). Samples were treated 2 × 2 min/day with solutions containing either, chitosan (50 or 500 mPas), porcine gastric mucin, F/Sn or combinations thereof after abrasive challenge. Tissue loss was measured profilometrically, interaction between hard tissue and active agents was assessed with energy dispersive spectroscopy and scanning electron microscopy. Chitosan and F/Sn showed the expected effect in reducing tissue loss under erosive and under erosive-abrasive conditions. Neither mucin alone nor the combinations with mucin showed any additional beneficial effect.Benedikt LukaVivien ArbterKathrin SanderAndrea DuerrschnabelNadine SchlueterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benedikt Luka Vivien Arbter Kathrin Sander Andrea Duerrschnabel Nadine Schlueter Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro
description	Abstract The application of stannous ions in combination with fluoride (F/Sn) is one of the central strategies in reducing erosive tooth wear. F/Sn efficacy can be enhanced by adding chitosan, a positively charged biopolymer. For patients with low saliva flow, this efficacy, however, is not sufficient, making further improvement desirable. This could be achieved by combining chitosan with other molecules like mucin, which together might form multilayers. This in-vitro study aimed to investigate the effect of chitosan, mucin, F/Sn and combinations thereof on enamel erosion and erosion-abrasion. Human enamel samples (n = 448, 28 groups) were cyclically eroded or eroded-abraded (10 days; 6 × 2 min erosion and 2 × 15 s/200 g abrasion per day). Samples were treated 2 × 2 min/day with solutions containing either, chitosan (50 or 500 mPas), porcine gastric mucin, F/Sn or combinations thereof after abrasive challenge. Tissue loss was measured profilometrically, interaction between hard tissue and active agents was assessed with energy dispersive spectroscopy and scanning electron microscopy. Chitosan and F/Sn showed the expected effect in reducing tissue loss under erosive and under erosive-abrasive conditions. Neither mucin alone nor the combinations with mucin showed any additional beneficial effect.
format	article
author	Benedikt Luka Vivien Arbter Kathrin Sander Andrea Duerrschnabel Nadine Schlueter
author_facet	Benedikt Luka Vivien Arbter Kathrin Sander Andrea Duerrschnabel Nadine Schlueter
author_sort	Benedikt Luka
title	Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro
title_short	Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro
title_full	Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro
title_fullStr	Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro
title_full_unstemmed	Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro
title_sort	impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or f/sn in enamel in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41342cb452b2427099cdc72b2d64abda
work_keys_str_mv	AT benediktluka impactofmucinontheantierosiveantiabrasiveefficacyofchitosanandorfsninenamelinvitro AT vivienarbter impactofmucinontheantierosiveantiabrasiveefficacyofchitosanandorfsninenamelinvitro AT kathrinsander impactofmucinontheantierosiveantiabrasiveefficacyofchitosanandorfsninenamelinvitro AT andreaduerrschnabel impactofmucinontheantierosiveantiabrasiveefficacyofchitosanandorfsninenamelinvitro AT nadineschlueter impactofmucinontheantierosiveantiabrasiveefficacyofchitosanandorfsninenamelinvitro
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Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro

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