Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction
Andrea Oleñik, Ignacio Mahillo-Fernández, Nicolás Alejandre-Alba, Guillermo Fernández-Sanz, María Alarcón Pérez, Sol Luxan, Silvia Quintana, Alfonso Martínez de Carneros Llorente, Blanca García-Sandov...
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Dove Medical Press
2014
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oai:doaj.org-article:413515b0582c41fa8a548aaf89f19b8b2021-12-02T02:07:32ZBenefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction1177-5483https://doaj.org/article/413515b0582c41fa8a548aaf89f19b8b2014-04-01T00:00:00Zhttp://www.dovepress.com/benefits-of-omega-3-fatty-acid-dietary-supplementation-on-health-relat-a16613https://doaj.org/toc/1177-5483 Andrea Oleñik, Ignacio Mahillo-Fernández, Nicolás Alejandre-Alba, Guillermo Fernández-Sanz, María Alarcón Pérez, Sol Luxan, Silvia Quintana, Alfonso Martínez de Carneros Llorente, Blanca García-Sandoval, Ignacio Jiménez-AlfaroDepartment of Ophthalmology, Fundación Jiménez Díaz, Madrid, SpainBackground: We assessed the impact of a dietary supplement based on the combination of omega-3 essential fatty acids and antioxidants on health-related quality of life in patients with meibomian gland dysfunction (MGD).Methods: Patients of either sex (aged 18–85 years) diagnosed with MGD according to criteria identified at a 2011 International Workshop on Meibomian Gland Dysfunction participated in this randomized, double-masked, placebo-controlled study. Group A patients (controls) received an oral placebo supplement and group B patients received the oral study supplement (Brudysec® 1.5 g; Brudy Laboratories, Barcelona, Spain). At baseline and at 3-month follow-up, the patients completed the 36-Item Short Form Health Survey questionnaire using a Spanish validated version. The Physical (PCS) and Mental (MCS) Component Summary scores were the main outcome variables.Results: A total of 61 patients completed the study (group A, n=31; group B, n=30). There were no significant differences in PCS and MCS scores at baseline between the two study groups, but after 3 months of treatment, significantly higher mean PCS and MSC scores were observed in patients treated with the active omega-3 dietary supplement as compared with controls (mean [standard deviation] PCS score 53.33±5.57 versus 47.46±7.31, P=0.008; mean MCS score 54.60±5.64 versus 47.80±8.45, P=0.0005). Moreover, mean differences between values at 3 months as compared with baseline were statistically significant for patients in group B (PCS score 7.14±5.81, 95% confidence interval 4.97–9.31, P=0.000; MCS score 5.96±7.64, 95% confidence interval 3.10–8.81, P=0.0002), whereas mean differences in patients assigned to group A were not statistically significant.Conclusion: Dietary supplementation with a combination of omega-3 essential fatty acids and antioxidants had a significant beneficial effect on HRQoL (health-related quality of life) in patients with MGD.Keywords: antioxidants, Brudysec®, nutraceuticals, polyunsaturated fatty acidsOleñik AMahillo-Fernández IAlejandre-Alba NFernández-Sanz GAlarcón Pérez MLuxan SQuintana SMartínez de Carneros Llorente AGarcía-Sandoval BJiménez-Alfaro IDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 831-836 (2014) |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Oleñik A Mahillo-Fernández I Alejandre-Alba N Fernández-Sanz G Alarcón Pérez M Luxan S Quintana S Martínez de Carneros Llorente A García-Sandoval B Jiménez-Alfaro I Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| description |
Andrea Oleñik, Ignacio Mahillo-Fernández, Nicolás Alejandre-Alba, Guillermo Fernández-Sanz, María Alarcón Pérez, Sol Luxan, Silvia Quintana, Alfonso Martínez de Carneros Llorente, Blanca García-Sandoval, Ignacio Jiménez-AlfaroDepartment of Ophthalmology, Fundación Jiménez Díaz, Madrid, SpainBackground: We assessed the impact of a dietary supplement based on the combination of omega-3 essential fatty acids and antioxidants on health-related quality of life in patients with meibomian gland dysfunction (MGD).Methods: Patients of either sex (aged 18–85 years) diagnosed with MGD according to criteria identified at a 2011 International Workshop on Meibomian Gland Dysfunction participated in this randomized, double-masked, placebo-controlled study. Group A patients (controls) received an oral placebo supplement and group B patients received the oral study supplement (Brudysec® 1.5 g; Brudy Laboratories, Barcelona, Spain). At baseline and at 3-month follow-up, the patients completed the 36-Item Short Form Health Survey questionnaire using a Spanish validated version. The Physical (PCS) and Mental (MCS) Component Summary scores were the main outcome variables.Results: A total of 61 patients completed the study (group A, n=31; group B, n=30). There were no significant differences in PCS and MCS scores at baseline between the two study groups, but after 3 months of treatment, significantly higher mean PCS and MSC scores were observed in patients treated with the active omega-3 dietary supplement as compared with controls (mean [standard deviation] PCS score 53.33±5.57 versus 47.46±7.31, P=0.008; mean MCS score 54.60±5.64 versus 47.80±8.45, P=0.0005). Moreover, mean differences between values at 3 months as compared with baseline were statistically significant for patients in group B (PCS score 7.14±5.81, 95% confidence interval 4.97–9.31, P=0.000; MCS score 5.96±7.64, 95% confidence interval 3.10–8.81, P=0.0002), whereas mean differences in patients assigned to group A were not statistically significant.Conclusion: Dietary supplementation with a combination of omega-3 essential fatty acids and antioxidants had a significant beneficial effect on HRQoL (health-related quality of life) in patients with MGD.Keywords: antioxidants, Brudysec®, nutraceuticals, polyunsaturated fatty acids |
| format |
article |
| author |
Oleñik A Mahillo-Fernández I Alejandre-Alba N Fernández-Sanz G Alarcón Pérez M Luxan S Quintana S Martínez de Carneros Llorente A García-Sandoval B Jiménez-Alfaro I |
| author_facet |
Oleñik A Mahillo-Fernández I Alejandre-Alba N Fernández-Sanz G Alarcón Pérez M Luxan S Quintana S Martínez de Carneros Llorente A García-Sandoval B Jiménez-Alfaro I |
| author_sort |
Oleñik A |
| title |
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| title_short |
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| title_full |
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| title_fullStr |
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| title_full_unstemmed |
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| title_sort |
benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/413515b0582c41fa8a548aaf89f19b8b |
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