Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

The use of stem cell-derived cardiomyocytes for heart repair is hampered by their immature structural and contractile properties that may cause arrhythmia. Here, Eng et al.show that electrical conditioning of human cardiomyocytes in 3D culture can enhance connectivity and provide resistance to arrhy...

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Autores principales:	George Eng, Benjamin W. Lee, Lev Protas, Mark Gagliardi, Kristy Brown, Robert S. Kass, Gordon Keller, Richard B. Robinson, Gordana Vunjak-Novakovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/413621c69f534affb5ac9f42218483c9
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id	oai:doaj.org-article:413621c69f534affb5ac9f42218483c9
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spelling	oai:doaj.org-article:413621c69f534affb5ac9f42218483c92021-12-02T15:35:42ZAutonomous beating rate adaptation in human stem cell-derived cardiomyocytes10.1038/ncomms103122041-1723https://doaj.org/article/413621c69f534affb5ac9f42218483c92016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10312https://doaj.org/toc/2041-1723The use of stem cell-derived cardiomyocytes for heart repair is hampered by their immature structural and contractile properties that may cause arrhythmia. Here, Eng et al.show that electrical conditioning of human cardiomyocytes in 3D culture can enhance connectivity and provide resistance to arrhythmia.George EngBenjamin W. LeeLev ProtasMark GagliardiKristy BrownRobert S. KassGordon KellerRichard B. RobinsonGordana Vunjak-NovakovicNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q George Eng Benjamin W. Lee Lev Protas Mark Gagliardi Kristy Brown Robert S. Kass Gordon Keller Richard B. Robinson Gordana Vunjak-Novakovic Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
description	The use of stem cell-derived cardiomyocytes for heart repair is hampered by their immature structural and contractile properties that may cause arrhythmia. Here, Eng et al.show that electrical conditioning of human cardiomyocytes in 3D culture can enhance connectivity and provide resistance to arrhythmia.
format	article
author	George Eng Benjamin W. Lee Lev Protas Mark Gagliardi Kristy Brown Robert S. Kass Gordon Keller Richard B. Robinson Gordana Vunjak-Novakovic
author_facet	George Eng Benjamin W. Lee Lev Protas Mark Gagliardi Kristy Brown Robert S. Kass Gordon Keller Richard B. Robinson Gordana Vunjak-Novakovic
author_sort	George Eng
title	Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
title_short	Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
title_full	Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
title_fullStr	Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
title_full_unstemmed	Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
title_sort	autonomous beating rate adaptation in human stem cell-derived cardiomyocytes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/413621c69f534affb5ac9f42218483c9
work_keys_str_mv	AT georgeeng autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT benjaminwlee autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT levprotas autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT markgagliardi autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT kristybrown autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT robertskass autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT gordonkeller autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT richardbrobinson autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes AT gordanavunjaknovakovic autonomousbeatingrateadaptationinhumanstemcellderivedcardiomyocytes
_version_	1718386468144021504

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

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