Prognostic role of oxytocin receptor in colon adenocarcinoma

The oxytocin receptor (OXTR) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of OXTR in the modulation of colon adenocarcinoma (COAD) growth, metastasis, and clinical prognosis remains to be eluc...

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Autores principales:	Sun Junjie, Xu Zhenyu, Mao Yong, Zhang Ting, Qin Yan, Hua Dong
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	oxytocin receptor colorectal cancer the cancer genome atlas poor prognosis immune infiltration Medicine R
Acceso en línea:	https://doaj.org/article/413644ea71534e8096ed0da63e3ed336
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spelling	oai:doaj.org-article:413644ea71534e8096ed0da63e3ed3362021-12-05T14:10:55ZPrognostic role of oxytocin receptor in colon adenocarcinoma2391-546310.1515/med-2021-0387https://doaj.org/article/413644ea71534e8096ed0da63e3ed3362021-11-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0387https://doaj.org/toc/2391-5463The oxytocin receptor (OXTR) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of OXTR in the modulation of colon adenocarcinoma (COAD) growth, metastasis, and clinical prognosis remains to be elucidated. This study used systematic bioinformatics analysis to explore the effects of OXTR on modulating COAD growth and prognosis in patients with COAD. Compared with normal tissues, OXTR mRNA level was higher in COAD tissues, which was associated with tumor progression. Elevated mRNA level of OXTR also indicated a poor prognosis in COAD patients. Furthermore, high mRNA level of OXTR was significantly associated with pathways involved in cell cycle regulation and signal transduction pathways, including the hedgehog, mTOR, TGF-β, and Wnt signaling pathways. OXTR expression was significantly correlated with the infiltration level of type 2T helper cell, central memory CD8 T cell, CD56 bright natural killer cell, activated CD8 T cell, activated B cell, and Type 1T helper cell. Moreover, silencing OXTR inhibited cell proliferation, migration, and invasion, and arrested the cell cycle. In conclusion, high mRNA level of OXTR indicates poor prognosis.Sun JunjieXu ZhenyuMao YongZhang TingQin YanHua DongDe Gruyterarticleoxytocin receptorcolorectal cancerthe cancer genome atlaspoor prognosisimmune infiltrationMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1762-1776 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxytocin receptor colorectal cancer the cancer genome atlas poor prognosis immune infiltration Medicine R
spellingShingle	oxytocin receptor colorectal cancer the cancer genome atlas poor prognosis immune infiltration Medicine R Sun Junjie Xu Zhenyu Mao Yong Zhang Ting Qin Yan Hua Dong Prognostic role of oxytocin receptor in colon adenocarcinoma
description	The oxytocin receptor (OXTR) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of OXTR in the modulation of colon adenocarcinoma (COAD) growth, metastasis, and clinical prognosis remains to be elucidated. This study used systematic bioinformatics analysis to explore the effects of OXTR on modulating COAD growth and prognosis in patients with COAD. Compared with normal tissues, OXTR mRNA level was higher in COAD tissues, which was associated with tumor progression. Elevated mRNA level of OXTR also indicated a poor prognosis in COAD patients. Furthermore, high mRNA level of OXTR was significantly associated with pathways involved in cell cycle regulation and signal transduction pathways, including the hedgehog, mTOR, TGF-β, and Wnt signaling pathways. OXTR expression was significantly correlated with the infiltration level of type 2T helper cell, central memory CD8 T cell, CD56 bright natural killer cell, activated CD8 T cell, activated B cell, and Type 1T helper cell. Moreover, silencing OXTR inhibited cell proliferation, migration, and invasion, and arrested the cell cycle. In conclusion, high mRNA level of OXTR indicates poor prognosis.
format	article
author	Sun Junjie Xu Zhenyu Mao Yong Zhang Ting Qin Yan Hua Dong
author_facet	Sun Junjie Xu Zhenyu Mao Yong Zhang Ting Qin Yan Hua Dong
author_sort	Sun Junjie
title	Prognostic role of oxytocin receptor in colon adenocarcinoma
title_short	Prognostic role of oxytocin receptor in colon adenocarcinoma
title_full	Prognostic role of oxytocin receptor in colon adenocarcinoma
title_fullStr	Prognostic role of oxytocin receptor in colon adenocarcinoma
title_full_unstemmed	Prognostic role of oxytocin receptor in colon adenocarcinoma
title_sort	prognostic role of oxytocin receptor in colon adenocarcinoma
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/413644ea71534e8096ed0da63e3ed336
work_keys_str_mv	AT sunjunjie prognosticroleofoxytocinreceptorincolonadenocarcinoma AT xuzhenyu prognosticroleofoxytocinreceptorincolonadenocarcinoma AT maoyong prognosticroleofoxytocinreceptorincolonadenocarcinoma AT zhangting prognosticroleofoxytocinreceptorincolonadenocarcinoma AT qinyan prognosticroleofoxytocinreceptorincolonadenocarcinoma AT huadong prognosticroleofoxytocinreceptorincolonadenocarcinoma
_version_	1718371598895939584

Prognostic role of oxytocin receptor in colon adenocarcinoma

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