Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State

'Background:' Dengue fever, (df) is a mosquito-borne disease caused by the dengue virus. Infection with dengue virus is a major cause of morbidity in the tropical and sub-tropical parts of the world. In about 60% of cases, it gives rise to undifferentiated fever which is clinically indisti...

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Autores principales:	Ahmadu Shehu Mohammed, Odekunle Bola Odegbemi, Chinedu Igwe, Nurudeen AA Hussain, Biobelu Abaye, Usman Oladipo Adekanye
Formato:	article
Lenguaje:	EN
Publicado:	University of New South Wales 2021
Materias:	dengue fever, febrile, military, immunoglobulins Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/413763dbb7664101a8361b01ad59be99
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spelling	oai:doaj.org-article:413763dbb7664101a8361b01ad59be992021-11-08T08:07:47ZPrevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State2652-003610.31646/gbio.110https://doaj.org/article/413763dbb7664101a8361b01ad59be992021-10-01T00:00:00Zhttps://jglobalbiosecurity.com/articles/110https://doaj.org/toc/2652-0036'Background:' Dengue fever, (df) is a mosquito-borne disease caused by the dengue virus. Infection with dengue virus is a major cause of morbidity in the tropical and sub-tropical parts of the world. In about 60% of cases, it gives rise to undifferentiated fever which is clinically indistinguishable from other viral infections. Dengue fever is known to occur in Nigeria, but the magnitude of this disease remains unclear. This study was done to determine the prevalence and determinants of df immunoglobulins (Ig) among patients attending a military hospital in Lagos. 'Methods:' Systematic random sampling was used to recruit participants. Study participants were patients presenting with febrile illness at Naval Medical Centre, Victoria Island, Lagos. A semi-structured, interviewer-administered questionnaire was used to collect data and 3 millilitres venous blood was drawn from each participant. Anti-dengue IgM and IgG was determined from whole blood using lateral flow chromatographic immunoassay in line with manufacturer’s instructions. Thick blood film was used for malaria microscopy. Epi-info version 7.2 was employed for data analysis using descriptive statistics and bivariate analysis at 5% level of significance. 'Results:' Mean age of study participants was 30.1 ± 13.6 years and 182 (59.9%) were males. The prevalence of df IgM and IgG was 8.5% and 18.0% respectively. Malaria-dengue fever co-infection was 10.8%. Individuals with malaria were twice less likely to have df (OR: 0.46, 95%CI: 0.27 - 0.78). Military personnel and their relations were about 3 times less likely to have df (OR: 0.35, 95%CI: 0.18 - 0.66). Joint pain was significantly associated with df (OR: 1.78, 95%CI: 1.05 - 2.99). 'Conclusions': A significant proportion of study population had both df IgM and IgG. Screening for df should be part of routine tests amongst patients that presents with febrile illness particularly those with joint pain.Ahmadu Shehu MohammedOdekunle Bola OdegbemiChinedu IgweNurudeen AA HussainBiobelu AbayeUsman Oladipo AdekanyeUniversity of New South Wales articledengue fever, febrile, military, immunoglobulinsInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENGlobal Biosecurity, Vol 3, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dengue fever, febrile, military, immunoglobulins Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	dengue fever, febrile, military, immunoglobulins Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Ahmadu Shehu Mohammed Odekunle Bola Odegbemi Chinedu Igwe Nurudeen AA Hussain Biobelu Abaye Usman Oladipo Adekanye Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State
description	'Background:' Dengue fever, (df) is a mosquito-borne disease caused by the dengue virus. Infection with dengue virus is a major cause of morbidity in the tropical and sub-tropical parts of the world. In about 60% of cases, it gives rise to undifferentiated fever which is clinically indistinguishable from other viral infections. Dengue fever is known to occur in Nigeria, but the magnitude of this disease remains unclear. This study was done to determine the prevalence and determinants of df immunoglobulins (Ig) among patients attending a military hospital in Lagos. 'Methods:' Systematic random sampling was used to recruit participants. Study participants were patients presenting with febrile illness at Naval Medical Centre, Victoria Island, Lagos. A semi-structured, interviewer-administered questionnaire was used to collect data and 3 millilitres venous blood was drawn from each participant. Anti-dengue IgM and IgG was determined from whole blood using lateral flow chromatographic immunoassay in line with manufacturer’s instructions. Thick blood film was used for malaria microscopy. Epi-info version 7.2 was employed for data analysis using descriptive statistics and bivariate analysis at 5% level of significance. 'Results:' Mean age of study participants was 30.1 ± 13.6 years and 182 (59.9%) were males. The prevalence of df IgM and IgG was 8.5% and 18.0% respectively. Malaria-dengue fever co-infection was 10.8%. Individuals with malaria were twice less likely to have df (OR: 0.46, 95%CI: 0.27 - 0.78). Military personnel and their relations were about 3 times less likely to have df (OR: 0.35, 95%CI: 0.18 - 0.66). Joint pain was significantly associated with df (OR: 1.78, 95%CI: 1.05 - 2.99). 'Conclusions': A significant proportion of study population had both df IgM and IgG. Screening for df should be part of routine tests amongst patients that presents with febrile illness particularly those with joint pain.
format	article
author	Ahmadu Shehu Mohammed Odekunle Bola Odegbemi Chinedu Igwe Nurudeen AA Hussain Biobelu Abaye Usman Oladipo Adekanye
author_facet	Ahmadu Shehu Mohammed Odekunle Bola Odegbemi Chinedu Igwe Nurudeen AA Hussain Biobelu Abaye Usman Oladipo Adekanye
author_sort	Ahmadu Shehu Mohammed
title	Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State
title_short	Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State
title_full	Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State
title_fullStr	Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State
title_full_unstemmed	Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State
title_sort	prevalence and determinants of dengue virus immunoglobulin among febrile patients attending naval medical centre victoria island, lagos state
publisher	University of New South Wales
publishDate	2021
url	https://doaj.org/article/413763dbb7664101a8361b01ad59be99
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Prevalence and Determinants of Dengue Virus Immunoglobulin among Febrile Patients Attending Naval Medical Centre Victoria Island, Lagos State

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