Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy

Abstract. Nurgaziyev M, Atenov Y, Khassenbekova Z, Akpanova S, Rysbekov K, Kozhakhmetov S, Nurgozhina A, Sergazy S, Chulenbayeva L, Ospanova Z, Tuyakova A, Mukhambetganov N, Sattybayeva R, Urazova S, Galymgozhina N, Zhumadilova A, Gulyaev A, Kushugulova A. 2020. Effect of mare’s milk prebiotic suppl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Madiyar Nurgaziyev, YERMEK AITENOV, ZHANAGUL KHASSENBEKOVA, SANIYA AKPANOVA, KAIRAT RYSBEKOV, SAMAT KOZHAKHMETOV, AYAULYM NURGOZHINA, SHYNGGYS SERGAZY, LAURA CHULENBAYEVA, ZHANNA OSPANOVA, ALTYNAI TUYAKOVA, NURISLAM MUKHAMBETGANOV, RASHIDA SATTYBAYEVA, SALTANAT URAZOVA, NAZYM GALYMGOZHINA, ANARA ZHUMADILOVA, ALEXANDR GULYAEV, ALMAGUL KUSHUGULOVA
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	antibiotic treatment, immune system, mare’s milk, microbiome Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/41387bf978984942b491db9f35d1545e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41387bf978984942b491db9f35d1545e
record_format	dspace
spelling	oai:doaj.org-article:41387bf978984942b491db9f35d1545e2021-11-22T00:44:11ZEffect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy1412-033X2085-472210.13057/biodiv/d211110https://doaj.org/article/41387bf978984942b491db9f35d1545e2020-10-01T00:00:00Zhttps://smujo.id/biodiv/article/view/6325https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Nurgaziyev M, Atenov Y, Khassenbekova Z, Akpanova S, Rysbekov K, Kozhakhmetov S, Nurgozhina A, Sergazy S, Chulenbayeva L, Ospanova Z, Tuyakova A, Mukhambetganov N, Sattybayeva R, Urazova S, Galymgozhina N, Zhumadilova A, Gulyaev A, Kushugulova A. 2020. Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy. Biodiversitas 21: 5065-5071. Antibiotic treatment can severely affect the gut microbiome for short-term and long-term consequences. Probiotic and prebiotic supplements are widely prescribed to modulate the composition and function of the human gut microbiome. The current study aims to determine the impacts of mare’s milk prebiotics on the diversity of gut bacterial communities and the local immune system when administered during and after a course of antibiotic therapy. Six children aged 4 to 5 years diagnosed with bilateral bronchopneumonia were prescribed cephalosporin (cefuroxime) antibiotics. During the 60 days of the study, three children consumed mare’s milk prebiotics, while the other three did not. Fecal samples were collected daily during antibiotic therapy and every five days after the last day of antibiotic treatment. Total DNA was isolated, and the taxonomic composition of the gut microbiome was analyzed by sequencing the 16S rRNA gene (V1-V3 region). The MULTIPLEX MAP platform was used to evaluate the local immune status. The relative abundance of 11 genera was reduced and did not recover until the last day of the study. The abundance of Bacteroides was not significantly altered in either group. Christensenella, Rothia, Abiotrophia, Acinetobacter, Anaerotruncus, Holdemania, and Turicibacter numbers were significantly increased on day five and remained at the same level during the study period. Cephalosporin administration also reduced the levels of pro-inflammatory and anti-inflammatory cytokines/chemokines (MIP1?, TNF?, GMCSF, GCSF, sCD40L, FGF2, TGF?, IL1?, and IP10).Madiyar NurgaziyevYERMEK AITENOVZHANAGUL KHASSENBEKOVASANIYA AKPANOVAKAIRAT RYSBEKOVSAMAT KOZHAKHMETOVAYAULYM NURGOZHINASHYNGGYS SERGAZYLAURA CHULENBAYEVAZHANNA OSPANOVAALTYNAI TUYAKOVANURISLAM MUKHAMBETGANOVRASHIDA SATTYBAYEVASALTANAT URAZOVANAZYM GALYMGOZHINAANARA ZHUMADILOVAALEXANDR GULYAEVALMAGUL KUSHUGULOVAMBI & UNS Soloarticleantibiotic treatment, immune system, mare’s milk, microbiomeBiology (General)QH301-705.5ENBiodiversitas, Vol 21, Iss 11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic treatment, immune system, mare’s milk, microbiome Biology (General) QH301-705.5
spellingShingle	antibiotic treatment, immune system, mare’s milk, microbiome Biology (General) QH301-705.5 Madiyar Nurgaziyev YERMEK AITENOV ZHANAGUL KHASSENBEKOVA SANIYA AKPANOVA KAIRAT RYSBEKOV SAMAT KOZHAKHMETOV AYAULYM NURGOZHINA SHYNGGYS SERGAZY LAURA CHULENBAYEVA ZHANNA OSPANOVA ALTYNAI TUYAKOVA NURISLAM MUKHAMBETGANOV RASHIDA SATTYBAYEVA SALTANAT URAZOVA NAZYM GALYMGOZHINA ANARA ZHUMADILOVA ALEXANDR GULYAEV ALMAGUL KUSHUGULOVA Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
description	Abstract. Nurgaziyev M, Atenov Y, Khassenbekova Z, Akpanova S, Rysbekov K, Kozhakhmetov S, Nurgozhina A, Sergazy S, Chulenbayeva L, Ospanova Z, Tuyakova A, Mukhambetganov N, Sattybayeva R, Urazova S, Galymgozhina N, Zhumadilova A, Gulyaev A, Kushugulova A. 2020. Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy. Biodiversitas 21: 5065-5071. Antibiotic treatment can severely affect the gut microbiome for short-term and long-term consequences. Probiotic and prebiotic supplements are widely prescribed to modulate the composition and function of the human gut microbiome. The current study aims to determine the impacts of mare’s milk prebiotics on the diversity of gut bacterial communities and the local immune system when administered during and after a course of antibiotic therapy. Six children aged 4 to 5 years diagnosed with bilateral bronchopneumonia were prescribed cephalosporin (cefuroxime) antibiotics. During the 60 days of the study, three children consumed mare’s milk prebiotics, while the other three did not. Fecal samples were collected daily during antibiotic therapy and every five days after the last day of antibiotic treatment. Total DNA was isolated, and the taxonomic composition of the gut microbiome was analyzed by sequencing the 16S rRNA gene (V1-V3 region). The MULTIPLEX MAP platform was used to evaluate the local immune status. The relative abundance of 11 genera was reduced and did not recover until the last day of the study. The abundance of Bacteroides was not significantly altered in either group. Christensenella, Rothia, Abiotrophia, Acinetobacter, Anaerotruncus, Holdemania, and Turicibacter numbers were significantly increased on day five and remained at the same level during the study period. Cephalosporin administration also reduced the levels of pro-inflammatory and anti-inflammatory cytokines/chemokines (MIP1?, TNF?, GMCSF, GCSF, sCD40L, FGF2, TGF?, IL1?, and IP10).
format	article
author	Madiyar Nurgaziyev YERMEK AITENOV ZHANAGUL KHASSENBEKOVA SANIYA AKPANOVA KAIRAT RYSBEKOV SAMAT KOZHAKHMETOV AYAULYM NURGOZHINA SHYNGGYS SERGAZY LAURA CHULENBAYEVA ZHANNA OSPANOVA ALTYNAI TUYAKOVA NURISLAM MUKHAMBETGANOV RASHIDA SATTYBAYEVA SALTANAT URAZOVA NAZYM GALYMGOZHINA ANARA ZHUMADILOVA ALEXANDR GULYAEV ALMAGUL KUSHUGULOVA
author_facet	Madiyar Nurgaziyev YERMEK AITENOV ZHANAGUL KHASSENBEKOVA SANIYA AKPANOVA KAIRAT RYSBEKOV SAMAT KOZHAKHMETOV AYAULYM NURGOZHINA SHYNGGYS SERGAZY LAURA CHULENBAYEVA ZHANNA OSPANOVA ALTYNAI TUYAKOVA NURISLAM MUKHAMBETGANOV RASHIDA SATTYBAYEVA SALTANAT URAZOVA NAZYM GALYMGOZHINA ANARA ZHUMADILOVA ALEXANDR GULYAEV ALMAGUL KUSHUGULOVA
author_sort	Madiyar Nurgaziyev
title	Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
title_short	Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
title_full	Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
title_fullStr	Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
title_full_unstemmed	Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
title_sort	effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/41387bf978984942b491db9f35d1545e
work_keys_str_mv	AT madiyarnurgaziyev effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT yermekaitenov effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT zhanagulkhassenbekova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT saniyaakpanova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT kairatrysbekov effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT samatkozhakhmetov effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT ayaulymnurgozhina effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT shynggyssergazy effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT laurachulenbayeva effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT zhannaospanova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT altynaituyakova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT nurislammukhambetganov effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT rashidasattybayeva effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT saltanaturazova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT nazymgalymgozhina effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT anarazhumadilova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT alexandrgulyaev effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy AT almagulkushugulova effectofmaresmilkprebioticsupplementationonthegutmicrobiomeandtheimmunesystemfollowingantibiotictherapy
_version_	1718418517152235520

Effect of mare’s milk prebiotic supplementation on the gut microbiome and the immune system following antibiotic therapy

Ejemplares similares