CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS

To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as ...

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Autores principales:	I. A. Kamaeva, N. L. Shaporova, I. M. Gaiduk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	бронхиальная астма, гипотиреоз тиреотоксикоз интерлейкин иммуноглобулин e Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/413b764a91044a169dd4b7546d900890
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spelling	oai:doaj.org-article:413b764a91044a169dd4b7546d9008902021-11-18T08:03:37ZCLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS1563-06252313-741X10.15789/1563-0625-2013-2-147-154https://doaj.org/article/413b764a91044a169dd4b7546d9008902014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/97https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTo reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more frequently in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged in BA patients, than in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum IgE levels were much increased in the group with BA + hyperthyroidism. The lowest IL-4/IFNγ ratio was revealed in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher in BA + hyperthyroidism group, than in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating in BA, whereas concomitant hypothyroidism may cause a reduction of Th2 immune response.I. A. KamaevaN. L. ShaporovaI. M. GaidukSPb RAACIarticleбронхиальная астма, гипотиреозтиреотоксикозинтерлейкиниммуноглобулин eImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 2, Pp 147-154 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	бронхиальная астма, гипотиреоз тиреотоксикоз интерлейкин иммуноглобулин e Immunologic diseases. Allergy RC581-607
spellingShingle	бронхиальная астма, гипотиреоз тиреотоксикоз интерлейкин иммуноглобулин e Immunologic diseases. Allergy RC581-607 I. A. Kamaeva N. L. Shaporova I. M. Gaiduk CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
description	To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more frequently in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged in BA patients, than in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum IgE levels were much increased in the group with BA + hyperthyroidism. The lowest IL-4/IFNγ ratio was revealed in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher in BA + hyperthyroidism group, than in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating in BA, whereas concomitant hypothyroidism may cause a reduction of Th2 immune response.
format	article
author	I. A. Kamaeva N. L. Shaporova I. M. Gaiduk
author_facet	I. A. Kamaeva N. L. Shaporova I. M. Gaiduk
author_sort	I. A. Kamaeva
title	CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
title_short	CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
title_full	CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
title_fullStr	CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
title_full_unstemmed	CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
title_sort	clinical and immunological features of bronchial asthma accompanied by thyroid gland disorders
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/413b764a91044a169dd4b7546d900890
work_keys_str_mv	AT iakamaeva clinicalandimmunologicalfeaturesofbronchialasthmaaccompaniedbythyroidglanddisorders AT nlshaporova clinicalandimmunologicalfeaturesofbronchialasthmaaccompaniedbythyroidglanddisorders AT imgaiduk clinicalandimmunologicalfeaturesofbronchialasthmaaccompaniedbythyroidglanddisorders
_version_	1718422538229383168

CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS

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