Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures

Abstract Preterm infants undergo early separation from parents and are exposed to frequent painful clinical procedures, with resultant short- and long-term effects on their neurodevelopment. We aimed to establish whether the mother’s voice could provide an effective and safe analgesia for preterm in...

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Autores principales:	Manuela Filippa, Maria Grazia Monaci, Carmen Spagnuolo, Paolo Serravalle, Roberta Daniele, Didier Grandjean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4143f4ae8a08422181ecd1329933ea9e
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spelling	oai:doaj.org-article:4143f4ae8a08422181ecd1329933ea9e2021-12-02T15:09:23ZMaternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures10.1038/s41598-021-96840-42045-2322https://doaj.org/article/4143f4ae8a08422181ecd1329933ea9e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96840-4https://doaj.org/toc/2045-2322Abstract Preterm infants undergo early separation from parents and are exposed to frequent painful clinical procedures, with resultant short- and long-term effects on their neurodevelopment. We aimed to establish whether the mother’s voice could provide an effective and safe analgesia for preterm infants and whether endogenous oxytocin (OXT) could be linked to pain modulation. Twenty preterm infants were exposed to three conditions—mother’s live voice (speaking or singing) and standard care—in random order during a painful procedure. OXT levels (pg/mL) in saliva and plasma cortisol levels were quantified, and the Premature Infant Pain Profile (PIPP) was blindly coded by trained psychologists. During the mother’s live voice, PIPP scores significantly decreased, with a concomitant increase in OXT levels over baseline. The effect on pain perception was marginally significant for singing. No effects on cortisol levels were found. The mother’s live voice modulated preterm infants’ pain indicators. Endogenous OXT released during vocal contact is a promising protective mechanism during early painful interventions in at-risk populations.Manuela FilippaMaria Grazia MonaciCarmen SpagnuoloPaolo SerravalleRoberta DanieleDidier GrandjeanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manuela Filippa Maria Grazia Monaci Carmen Spagnuolo Paolo Serravalle Roberta Daniele Didier Grandjean Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
description	Abstract Preterm infants undergo early separation from parents and are exposed to frequent painful clinical procedures, with resultant short- and long-term effects on their neurodevelopment. We aimed to establish whether the mother’s voice could provide an effective and safe analgesia for preterm infants and whether endogenous oxytocin (OXT) could be linked to pain modulation. Twenty preterm infants were exposed to three conditions—mother’s live voice (speaking or singing) and standard care—in random order during a painful procedure. OXT levels (pg/mL) in saliva and plasma cortisol levels were quantified, and the Premature Infant Pain Profile (PIPP) was blindly coded by trained psychologists. During the mother’s live voice, PIPP scores significantly decreased, with a concomitant increase in OXT levels over baseline. The effect on pain perception was marginally significant for singing. No effects on cortisol levels were found. The mother’s live voice modulated preterm infants’ pain indicators. Endogenous OXT released during vocal contact is a promising protective mechanism during early painful interventions in at-risk populations.
format	article
author	Manuela Filippa Maria Grazia Monaci Carmen Spagnuolo Paolo Serravalle Roberta Daniele Didier Grandjean
author_facet	Manuela Filippa Maria Grazia Monaci Carmen Spagnuolo Paolo Serravalle Roberta Daniele Didier Grandjean
author_sort	Manuela Filippa
title	Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
title_short	Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
title_full	Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
title_fullStr	Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
title_full_unstemmed	Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
title_sort	maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4143f4ae8a08422181ecd1329933ea9e
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Maternal speech decreases pain scores and increases oxytocin levels in preterm infants during painful procedures

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