Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion.

Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion.

Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown to act as haploinsufficient tumor suppressors. How the deregulation of miRNA b...

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Autores principales: Karen Cawley, Susan E Logue, Adrienne M Gorman, Qingping Zeng, John Patterson, Sanjeev Gupta, Afshin Samali
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4145669fbed445928aa3b8e5b672123d
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