SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells

SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells

While the immunomodulatory pathways initiated in immune cells contribute to therapeutic response, their activation in cancer cells play a role in cancer progression. Also, many of the aberrantly expressed immunomodulators on cancer cells are considered as therapeutic targets. Here, we introduce host...

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Bibliographic Details
Main Authors: Shyla Gopalakrishnan, Soumya Krishnan Uma, Gayathri Mohan, Amrutha Mohan, Geetha Shanmugam, Vineeth T. V. Kumar, Sreekumar J, Sivakumar K. Chandrika, Dileep Vasudevan, Sai Ravi Chandra Nori, Shijulal Nelson Sathi, Sanil George, Tessy Thomas Maliekal
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
host defense peptides
temporins
immunoregulation
JNK/AP1 pathway
cancer
apoptosis
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/41457526d2a84c1d81a6c729af043fa3
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