Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury

Spinal cord injury (SCI) is a devastating disease leading to loss of sensory and motor functions, whose pathological process includes mechanical primary injury and secondary injury. Macrophages play an important role in SCI pathology. According to its origin, it can be divided into resident microgli...

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Autores principales:	Yuanzhe Ding, Di Zhang, Sheng Wang, Xiaolei Zhang, Jingquan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	spinal cord injury hematogenous macrophages microglia inflammation therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4146446bdace48868d06af4396047694
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spelling	oai:doaj.org-article:4146446bdace48868d06af43960476942021-11-30T19:50:16ZHematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury2296-634X10.3389/fcell.2021.767888https://doaj.org/article/4146446bdace48868d06af43960476942021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.767888/fullhttps://doaj.org/toc/2296-634XSpinal cord injury (SCI) is a devastating disease leading to loss of sensory and motor functions, whose pathological process includes mechanical primary injury and secondary injury. Macrophages play an important role in SCI pathology. According to its origin, it can be divided into resident microglia and peripheral monocyte-derived macrophages (hematogenous Mφ). And it can also be divided into M1-type macrophages and M2-type macrophages on the basis of its functional characteristics. Hematogenous macrophages may contribute to the SCI process through infiltrating, scar forming, phagocytizing debris, and inducing inflammatory response. Although some of the activities of hematogenous macrophages are shown to be beneficial, the role of hematogenous macrophages in SCI remains controversial. In this review, following a brief introduction of hematogenous macrophages, we mainly focus on the function and the controversial role of hematogenous macrophages in SCI, and we propose that hematogenous macrophages may be a new therapeutic target for SCI.Yuanzhe DingYuanzhe DingDi ZhangDi ZhangDi ZhangSheng WangSheng WangSheng WangXiaolei ZhangXiaolei ZhangXiaolei ZhangXiaolei ZhangJingquan YangJingquan YangJingquan YangFrontiers Media S.A.articlespinal cord injuryhematogenous macrophagesmicrogliainflammationtherapyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury hematogenous macrophages microglia inflammation therapy Biology (General) QH301-705.5
spellingShingle	spinal cord injury hematogenous macrophages microglia inflammation therapy Biology (General) QH301-705.5 Yuanzhe Ding Yuanzhe Ding Di Zhang Di Zhang Di Zhang Sheng Wang Sheng Wang Sheng Wang Xiaolei Zhang Xiaolei Zhang Xiaolei Zhang Xiaolei Zhang Jingquan Yang Jingquan Yang Jingquan Yang Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury
description	Spinal cord injury (SCI) is a devastating disease leading to loss of sensory and motor functions, whose pathological process includes mechanical primary injury and secondary injury. Macrophages play an important role in SCI pathology. According to its origin, it can be divided into resident microglia and peripheral monocyte-derived macrophages (hematogenous Mφ). And it can also be divided into M1-type macrophages and M2-type macrophages on the basis of its functional characteristics. Hematogenous macrophages may contribute to the SCI process through infiltrating, scar forming, phagocytizing debris, and inducing inflammatory response. Although some of the activities of hematogenous macrophages are shown to be beneficial, the role of hematogenous macrophages in SCI remains controversial. In this review, following a brief introduction of hematogenous macrophages, we mainly focus on the function and the controversial role of hematogenous macrophages in SCI, and we propose that hematogenous macrophages may be a new therapeutic target for SCI.
format	article
author	Yuanzhe Ding Yuanzhe Ding Di Zhang Di Zhang Di Zhang Sheng Wang Sheng Wang Sheng Wang Xiaolei Zhang Xiaolei Zhang Xiaolei Zhang Xiaolei Zhang Jingquan Yang Jingquan Yang Jingquan Yang
author_facet	Yuanzhe Ding Yuanzhe Ding Di Zhang Di Zhang Di Zhang Sheng Wang Sheng Wang Sheng Wang Xiaolei Zhang Xiaolei Zhang Xiaolei Zhang Xiaolei Zhang Jingquan Yang Jingquan Yang Jingquan Yang
author_sort	Yuanzhe Ding
title	Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury
title_short	Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury
title_full	Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury
title_fullStr	Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury
title_full_unstemmed	Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury
title_sort	hematogenous macrophages: a new therapeutic target for spinal cord injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4146446bdace48868d06af4396047694
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Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury

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