Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle

Abstract Vertical sleeve gastrectomy (VSG) is the most commonly performed bariatric/metabolic surgery, exhibiting a high rate of diabetes remission in humans. To elucidate the molecular mechanisms of VSG, we performed transcriptomic analysis of the liver, fat, and muscle in VSG mice. C57BL/6 mice fe...

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Autores principales:	Chang Ho Ahn, Eun Hye Choi, Hyunjung Lee, Woochan Lee, Jong-Il Kim, Young Min Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4146aba13afb4c189ee265903bb35056
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spelling	oai:doaj.org-article:4146aba13afb4c189ee265903bb350562021-12-02T14:16:42ZVertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle10.1038/s41598-021-81866-52045-2322https://doaj.org/article/4146aba13afb4c189ee265903bb350562021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81866-5https://doaj.org/toc/2045-2322Abstract Vertical sleeve gastrectomy (VSG) is the most commonly performed bariatric/metabolic surgery, exhibiting a high rate of diabetes remission in humans. To elucidate the molecular mechanisms of VSG, we performed transcriptomic analysis of the liver, fat, and muscle in VSG mice. C57BL/6 mice fed a high-fat diet were randomly assigned to sham or VSG surgery. The sham-operated mice were fed ad libitum (sham group) or pair-fed (sham-PF group) matching their food intake to the VSG-operated mice. Comparative transcriptomic analysis of the liver, fat, and muscle using RNA sequencing was performed. VSG reduced body weight and improved glucose tolerance compared to the sham group, but not more than the sham-PF group. Improvement in fatty liver and adipose tissue inflammation was comparable between VSG and sham-PF. However, global gene expression profiles showed distinctive changes in the liver, fat, and muscle of the VSG group compared to both the sham or sham-PF groups. The liver showed the most prominent gene expression changes. Immune response-related pathways were commonly upregulated in the three organs of the VSG group compared to the sham or sham-PF. VSG induces organ-specific gene expression changes in the liver, fat, and muscle, which may play critical roles in metabolic improvements after VSG.Chang Ho AhnEun Hye ChoiHyunjung LeeWoochan LeeJong-Il KimYoung Min ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chang Ho Ahn Eun Hye Choi Hyunjung Lee Woochan Lee Jong-Il Kim Young Min Cho Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
description	Abstract Vertical sleeve gastrectomy (VSG) is the most commonly performed bariatric/metabolic surgery, exhibiting a high rate of diabetes remission in humans. To elucidate the molecular mechanisms of VSG, we performed transcriptomic analysis of the liver, fat, and muscle in VSG mice. C57BL/6 mice fed a high-fat diet were randomly assigned to sham or VSG surgery. The sham-operated mice were fed ad libitum (sham group) or pair-fed (sham-PF group) matching their food intake to the VSG-operated mice. Comparative transcriptomic analysis of the liver, fat, and muscle using RNA sequencing was performed. VSG reduced body weight and improved glucose tolerance compared to the sham group, but not more than the sham-PF group. Improvement in fatty liver and adipose tissue inflammation was comparable between VSG and sham-PF. However, global gene expression profiles showed distinctive changes in the liver, fat, and muscle of the VSG group compared to both the sham or sham-PF groups. The liver showed the most prominent gene expression changes. Immune response-related pathways were commonly upregulated in the three organs of the VSG group compared to the sham or sham-PF. VSG induces organ-specific gene expression changes in the liver, fat, and muscle, which may play critical roles in metabolic improvements after VSG.
format	article
author	Chang Ho Ahn Eun Hye Choi Hyunjung Lee Woochan Lee Jong-Il Kim Young Min Cho
author_facet	Chang Ho Ahn Eun Hye Choi Hyunjung Lee Woochan Lee Jong-Il Kim Young Min Cho
author_sort	Chang Ho Ahn
title	Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
title_short	Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
title_full	Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
title_fullStr	Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
title_full_unstemmed	Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
title_sort	vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4146aba13afb4c189ee265903bb35056
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Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle

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