Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note

PurposeThe safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that ar...

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Autores principales:	Thomas Noh, Parikshit Juvekar, Raymond Huang, Gunnar Lee, Christian T. Ogasawara, Alexandra J. Golby
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	laser interstitial thermal therapy LITT magnetic resonance thermometry MRT brain tumors biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4146aecbf8d24290b1d839f71761b6c1
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spelling	oai:doaj.org-article:4146aecbf8d24290b1d839f71761b6c12021-11-18T09:32:45ZBiopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note2234-943X10.3389/fonc.2021.746416https://doaj.org/article/4146aecbf8d24290b1d839f71761b6c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.746416/fullhttps://doaj.org/toc/2234-943XPurposeThe safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that are especially sensitive to susceptibility effects from air and blood. LITT for brain tumors is often preceded by a biopsy and is anecdotally associated with artifact during ablation. Thus, we reviewed our experience and describe the qualitative signal dropout that can interfere with ablation.MethodsWe retrospectively reviewed all LITT cases performed in our intraoperative MRI suite for tumors between 2017 and 2020. We identified a total of 17 LITT cases. Cases were reviewed for age, sex, pathology, presence of artifact, operative technique, and presence of blood/air on post-operative scans.ResultsWe identified six cases that were preceded by biopsy, all six had artifact present during ablation, and all six were noted to have air/blood on their post-operative MRI or CT scans. In two of those cases, the artifactual signal dropout qualitatively interfered with thermal damage thresholds at the borders of the tumor. There was no artifact in the 11 non-biopsy cases and no obvious blood or air was noted on the post-ablation scans.ConclusionAdditional consideration should be given to pre-LITT biopsies. The presence of air/blood caused an artifactual signal dropout effect in cases with biopsy that was severe enough to interfere with ablation in a significant number of those cases. Additional studies are needed to identify modifying strategies.Thomas NohParikshit JuvekarRaymond HuangGunnar LeeChristian T. OgasawaraAlexandra J. GolbyFrontiers Media S.A.articlelaser interstitial thermal therapyLITTmagnetic resonance thermometryMRTbrain tumorsbiopsyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	laser interstitial thermal therapy LITT magnetic resonance thermometry MRT brain tumors biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	laser interstitial thermal therapy LITT magnetic resonance thermometry MRT brain tumors biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Thomas Noh Parikshit Juvekar Raymond Huang Gunnar Lee Christian T. Ogasawara Alexandra J. Golby Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
description	PurposeThe safety and effectiveness of laser interstitial thermal therapy (LITT) relies critically on the ability to continuously monitor the ablation based on real-time temperature mapping using magnetic resonance thermometry (MRT). This technique uses gradient recalled echo (GRE) sequences that are especially sensitive to susceptibility effects from air and blood. LITT for brain tumors is often preceded by a biopsy and is anecdotally associated with artifact during ablation. Thus, we reviewed our experience and describe the qualitative signal dropout that can interfere with ablation.MethodsWe retrospectively reviewed all LITT cases performed in our intraoperative MRI suite for tumors between 2017 and 2020. We identified a total of 17 LITT cases. Cases were reviewed for age, sex, pathology, presence of artifact, operative technique, and presence of blood/air on post-operative scans.ResultsWe identified six cases that were preceded by biopsy, all six had artifact present during ablation, and all six were noted to have air/blood on their post-operative MRI or CT scans. In two of those cases, the artifactual signal dropout qualitatively interfered with thermal damage thresholds at the borders of the tumor. There was no artifact in the 11 non-biopsy cases and no obvious blood or air was noted on the post-ablation scans.ConclusionAdditional consideration should be given to pre-LITT biopsies. The presence of air/blood caused an artifactual signal dropout effect in cases with biopsy that was severe enough to interfere with ablation in a significant number of those cases. Additional studies are needed to identify modifying strategies.
format	article
author	Thomas Noh Parikshit Juvekar Raymond Huang Gunnar Lee Christian T. Ogasawara Alexandra J. Golby
author_facet	Thomas Noh Parikshit Juvekar Raymond Huang Gunnar Lee Christian T. Ogasawara Alexandra J. Golby
author_sort	Thomas Noh
title	Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_short	Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_full	Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_fullStr	Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_full_unstemmed	Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note
title_sort	biopsy artifact in laser interstitial thermal therapy: a technical note
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4146aecbf8d24290b1d839f71761b6c1
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Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note

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