Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model

Abstract Cold atmospheric plasma (CAP) has been incorporated into various fields, including promotion of cutaneous wound healing. Atopic dermatitis (AD) is a chronic cutaneous condition characterized by inflammation-induced skin wounds and impaired skin barrier function. To investigate whether CAP m...

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Autores principales:	Ik Jun Moon, Mi Ra Yun, Hae Kyeong Yoon, Keon Hee Lee, Sun Young Choi, Woo Jin Lee, Sung Eun Chang, Chong Hyun Won
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4148a8a838bd4aac8dccc0ff1fe806c1
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spelling	oai:doaj.org-article:4148a8a838bd4aac8dccc0ff1fe806c12021-12-02T18:50:47ZTreatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model10.1038/s41598-021-95471-z2045-2322https://doaj.org/article/4148a8a838bd4aac8dccc0ff1fe806c12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95471-zhttps://doaj.org/toc/2045-2322Abstract Cold atmospheric plasma (CAP) has been incorporated into various fields, including promotion of cutaneous wound healing. Atopic dermatitis (AD) is a chronic cutaneous condition characterized by inflammation-induced skin wounds and impaired skin barrier function. To investigate whether CAP may improve AD using an animal model. Dermatophagoides farinae extracts (DFE)-induced murine models of AD were used in this study. The plasma-treated group received a total of 6 CAP treatments during 2 weeks, while the control group did not receive any treatment. Differences in dermatitis severity, transepidermal water loss (TEWL), serum level of immunoglobulin (Ig) E and epidermal thickness were evaluated in both groups. The dermatitis severity was significantly improved by CAP treatment. TEWL was lower in the plasma-treated group compared with the non-treated control group. Serum Ig E dropped significantly after treatment with CAP. Difference in epidermal thickness of the ear skin was not significant between the plasma-treated and non-treated groups. Localized treatment of AD with CAP decreases dermatitis severity, TEWL, and serum Ig E level. These results show CAP’s potentials as a novel therapeutic modality for AD.Ik Jun MoonMi Ra YunHae Kyeong YoonKeon Hee LeeSun Young ChoiWoo Jin LeeSung Eun ChangChong Hyun WonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ik Jun Moon Mi Ra Yun Hae Kyeong Yoon Keon Hee Lee Sun Young Choi Woo Jin Lee Sung Eun Chang Chong Hyun Won Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
description	Abstract Cold atmospheric plasma (CAP) has been incorporated into various fields, including promotion of cutaneous wound healing. Atopic dermatitis (AD) is a chronic cutaneous condition characterized by inflammation-induced skin wounds and impaired skin barrier function. To investigate whether CAP may improve AD using an animal model. Dermatophagoides farinae extracts (DFE)-induced murine models of AD were used in this study. The plasma-treated group received a total of 6 CAP treatments during 2 weeks, while the control group did not receive any treatment. Differences in dermatitis severity, transepidermal water loss (TEWL), serum level of immunoglobulin (Ig) E and epidermal thickness were evaluated in both groups. The dermatitis severity was significantly improved by CAP treatment. TEWL was lower in the plasma-treated group compared with the non-treated control group. Serum Ig E dropped significantly after treatment with CAP. Difference in epidermal thickness of the ear skin was not significant between the plasma-treated and non-treated groups. Localized treatment of AD with CAP decreases dermatitis severity, TEWL, and serum Ig E level. These results show CAP’s potentials as a novel therapeutic modality for AD.
format	article
author	Ik Jun Moon Mi Ra Yun Hae Kyeong Yoon Keon Hee Lee Sun Young Choi Woo Jin Lee Sung Eun Chang Chong Hyun Won
author_facet	Ik Jun Moon Mi Ra Yun Hae Kyeong Yoon Keon Hee Lee Sun Young Choi Woo Jin Lee Sung Eun Chang Chong Hyun Won
author_sort	Ik Jun Moon
title	Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
title_short	Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
title_full	Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
title_fullStr	Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
title_full_unstemmed	Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
title_sort	treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4148a8a838bd4aac8dccc0ff1fe806c1
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Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model

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