Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam

Objective: Data on the management and outcomes of acute myocarditis treated with extracorporeal membrane oxygenation (ECMO) among low- and middle-income countries are limited. This study aimed to determine the short-term outcomes and also identify factors associated with ECMO use among children with...

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Autores principales:	Ta Anh Tuan, Tran Dang Xoay, Phan Huu Phuc, Dau Viet Hung, Nguyen Trong Dung, Nguyen Ly Thinh Truong, Nguyen Van Thuan, Tran Minh Dien
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acute myocarditis cardiac arrhythmia extracorporeal membrane oxygenation mortality pediatrics Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/4148d2d47f8440b3b9c06235409420c9
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spelling	oai:doaj.org-article:4148d2d47f8440b3b9c06235409420c92021-12-01T13:17:12ZPediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam2297-055X10.3389/fcvm.2021.741260https://doaj.org/article/4148d2d47f8440b3b9c06235409420c92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.741260/fullhttps://doaj.org/toc/2297-055XObjective: Data on the management and outcomes of acute myocarditis treated with extracorporeal membrane oxygenation (ECMO) among low- and middle-income countries are limited. This study aimed to determine the short-term outcomes and also identify factors associated with ECMO use among children with acute myocarditis at a tertiary children's hospital in Vietnam.Methods: A single-center, retrospective observational study was conducted between January 2016 and February 2021. Pediatric patients with acute myocarditis, aged 1 month to 16 years, were included.Results: In total, 54 patients (male, 46%; median age, 7 years) with acute myocarditis were included; 37 of them received ECMO support. Thirty percent (16/54) of the patients died, and 12 of them received ECMO. Laboratory variables that differed between survivors and non-survivors included median left ventricular ejection fraction (LVEF) at 48 h (42 vs. 25%; p = 0.001), platelet count (304 g/L [interquartile range (IQR): 243–271] vs. 219 g/L [IQR: 167–297]; p = 0.014), and protein (60 g/dl [IQR: 54–69] vs. 55 [IQR: 50–58]; p = 0.025). Among patients who received ECMO, compared with the survivors, non-survivors had a low LVEF at 48 h (odds ratio (OR), 0.8; 95% confidence interval (CI): 0.6–0.9; p = 0.006) and high vasoactive-inotropic score (OR, 1.0; 95% CI: 1.0–1.0; p = 0.038) and lactate (OR, 2.8; 95% CI, 1.2–6.1; p = 0.013) at 24 h post-ECMO.Conclusions: The case fatality rate among children with acute myocarditis was 30 and 32% among patients requiring ECMO support. Arrhythmia was an indicator for ECMO in patients with cardiogenic shock.Ta Anh TuanTa Anh TuanTa Anh TuanTran Dang XoayPhan Huu PhucDau Viet HungDau Viet HungNguyen Trong DungNguyen Ly Thinh TruongNguyen Van ThuanTran Minh DienTran Minh DienFrontiers Media S.A.articleacute myocarditiscardiac arrhythmiaextracorporeal membrane oxygenationmortalitypediatricsDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute myocarditis cardiac arrhythmia extracorporeal membrane oxygenation mortality pediatrics Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	acute myocarditis cardiac arrhythmia extracorporeal membrane oxygenation mortality pediatrics Diseases of the circulatory (Cardiovascular) system RC666-701 Ta Anh Tuan Ta Anh Tuan Ta Anh Tuan Tran Dang Xoay Phan Huu Phuc Dau Viet Hung Dau Viet Hung Nguyen Trong Dung Nguyen Ly Thinh Truong Nguyen Van Thuan Tran Minh Dien Tran Minh Dien Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam
description	Objective: Data on the management and outcomes of acute myocarditis treated with extracorporeal membrane oxygenation (ECMO) among low- and middle-income countries are limited. This study aimed to determine the short-term outcomes and also identify factors associated with ECMO use among children with acute myocarditis at a tertiary children's hospital in Vietnam.Methods: A single-center, retrospective observational study was conducted between January 2016 and February 2021. Pediatric patients with acute myocarditis, aged 1 month to 16 years, were included.Results: In total, 54 patients (male, 46%; median age, 7 years) with acute myocarditis were included; 37 of them received ECMO support. Thirty percent (16/54) of the patients died, and 12 of them received ECMO. Laboratory variables that differed between survivors and non-survivors included median left ventricular ejection fraction (LVEF) at 48 h (42 vs. 25%; p = 0.001), platelet count (304 g/L [interquartile range (IQR): 243–271] vs. 219 g/L [IQR: 167–297]; p = 0.014), and protein (60 g/dl [IQR: 54–69] vs. 55 [IQR: 50–58]; p = 0.025). Among patients who received ECMO, compared with the survivors, non-survivors had a low LVEF at 48 h (odds ratio (OR), 0.8; 95% confidence interval (CI): 0.6–0.9; p = 0.006) and high vasoactive-inotropic score (OR, 1.0; 95% CI: 1.0–1.0; p = 0.038) and lactate (OR, 2.8; 95% CI, 1.2–6.1; p = 0.013) at 24 h post-ECMO.Conclusions: The case fatality rate among children with acute myocarditis was 30 and 32% among patients requiring ECMO support. Arrhythmia was an indicator for ECMO in patients with cardiogenic shock.
format	article
author	Ta Anh Tuan Ta Anh Tuan Ta Anh Tuan Tran Dang Xoay Phan Huu Phuc Dau Viet Hung Dau Viet Hung Nguyen Trong Dung Nguyen Ly Thinh Truong Nguyen Van Thuan Tran Minh Dien Tran Minh Dien
author_facet	Ta Anh Tuan Ta Anh Tuan Ta Anh Tuan Tran Dang Xoay Phan Huu Phuc Dau Viet Hung Dau Viet Hung Nguyen Trong Dung Nguyen Ly Thinh Truong Nguyen Van Thuan Tran Minh Dien Tran Minh Dien
author_sort	Ta Anh Tuan
title	Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam
title_short	Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam
title_full	Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam
title_fullStr	Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam
title_full_unstemmed	Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam
title_sort	pediatric acute myocarditis with short-term outcomes and factors for extracorporeal membrane oxygenation: a single-center retrospective cohort study in vietnam
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4148d2d47f8440b3b9c06235409420c9
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Pediatric Acute Myocarditis With Short-Term Outcomes and Factors for Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study in Vietnam

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