The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

The aim of our study was to evaluate nitrosooxidative status, the content of hydrogen sulphide and cortisol in blood serum of patients with a II stage arterial hypertension under the conditions of physical exertion. Material and Methods.Thirtypatients with II stage arterial hypertension were exam...

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Autores principales:	I.S. Dronyk, O.Y. Yavorsky, O.Y. Sklyarov, R.S. Pshyk
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2019
Materias:	nitric oxide, hydrogen sulfide, l-arginine, nitrite anion, arterial hypertension Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4149552afd15452abf8cc262a93bb0d6
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spelling	oai:doaj.org-article:4149552afd15452abf8cc262a93bb0d62021-11-10T19:49:52ZThe changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension1029-42442415-330310.25040/aml2019.01.017https://doaj.org/article/4149552afd15452abf8cc262a93bb0d62019-02-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/69https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303The aim of our study was to evaluate nitrosooxidative status, the content of hydrogen sulphide and cortisol in blood serum of patients with a II stage arterial hypertension under the conditions of physical exertion. Material and Methods.Thirtypatients with II stage arterial hypertension were examined. The examined patients were exposed to two-stage physical exertionusing veloergometer with the intensity of 50 and 75 % of the proper maximal oxygen uptake (MOU) of the body. Results and Discussion. In blood serum of patients before and after physical exertionthe content of TBA-active products, hydrogen sulphide, L-arginine, nitric anion, sum of nitrite-nitrate, cortisol, activity of SOD, catalase, and arginase were determined. A significant increase of L-arginine and hydrogen sulphide against a background of the decrease of nitrite-anion and sum of nitrite-nitrate was noted. It may be suggested that in individuals with hypertension under the influence of physical exertion thesynthesis of NO decreases and vasodilatation and vasoprotection occur by means of increase of the hydrogen sulphide level. Conclusions.The increase of the level of L-arginine and hydrogen sulphide as well as the decrease of nitrite-anion level may be considered to be markers of evaluation of immediate changes in patients with arterial hypertension after physical exertion. The response rate of enzyme systems caused by physical activity differs among patients with an increase in blood pressure.I.S. DronykO.Y. YavorskyO.Y. SklyarovR.S. PshykDanylo Halytsky Lviv National Medical Universityarticlenitric oxide, hydrogen sulfide, l-arginine, nitrite anion, arterial hypertensionMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 25, Iss 1, Pp 17-22 (2019)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	nitric oxide, hydrogen sulfide, l-arginine, nitrite anion, arterial hypertension Medicine (General) R5-920
spellingShingle	nitric oxide, hydrogen sulfide, l-arginine, nitrite anion, arterial hypertension Medicine (General) R5-920 I.S. Dronyk O.Y. Yavorsky O.Y. Sklyarov R.S. Pshyk The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
description	The aim of our study was to evaluate nitrosooxidative status, the content of hydrogen sulphide and cortisol in blood serum of patients with a II stage arterial hypertension under the conditions of physical exertion. Material and Methods.Thirtypatients with II stage arterial hypertension were examined. The examined patients were exposed to two-stage physical exertionusing veloergometer with the intensity of 50 and 75 % of the proper maximal oxygen uptake (MOU) of the body. Results and Discussion. In blood serum of patients before and after physical exertionthe content of TBA-active products, hydrogen sulphide, L-arginine, nitric anion, sum of nitrite-nitrate, cortisol, activity of SOD, catalase, and arginase were determined. A significant increase of L-arginine and hydrogen sulphide against a background of the decrease of nitrite-anion and sum of nitrite-nitrate was noted. It may be suggested that in individuals with hypertension under the influence of physical exertion thesynthesis of NO decreases and vasodilatation and vasoprotection occur by means of increase of the hydrogen sulphide level. Conclusions.The increase of the level of L-arginine and hydrogen sulphide as well as the decrease of nitrite-anion level may be considered to be markers of evaluation of immediate changes in patients with arterial hypertension after physical exertion. The response rate of enzyme systems caused by physical activity differs among patients with an increase in blood pressure.
format	article
author	I.S. Dronyk O.Y. Yavorsky O.Y. Sklyarov R.S. Pshyk
author_facet	I.S. Dronyk O.Y. Yavorsky O.Y. Sklyarov R.S. Pshyk
author_sort	I.S. Dronyk
title	The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
title_short	The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
title_full	The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
title_fullStr	The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
title_full_unstemmed	The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
title_sort	changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2019
url	https://doaj.org/article/4149552afd15452abf8cc262a93bb0d6
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The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

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