Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis

Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis

EphA2/ErbB2 complex is important in promoting breast cancer but the mechanism by which these receptor tyrosine kinases are exported from the endoplasmic reticulum is unknown. Here the authors show that Anks1a acts as a cargo adaptor in sorting EphA2 into COPII vesicles, thus modulating the surface l...

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Main Authors: Haeryung Lee, Hyuna Noh, Jiyoung Mun, Changkyu Gu, Sanja Sever, Soochul Park
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/414a168e7d8b4e848a820339ce79c82f
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spelling oai:doaj.org-article:414a168e7d8b4e848a820339ce79c82f2021-12-02T14:39:54ZAnks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis10.1038/ncomms127992041-1723https://doaj.org/article/414a168e7d8b4e848a820339ce79c82f2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12799https://doaj.org/toc/2041-1723EphA2/ErbB2 complex is important in promoting breast cancer but the mechanism by which these receptor tyrosine kinases are exported from the endoplasmic reticulum is unknown. Here the authors show that Anks1a acts as a cargo adaptor in sorting EphA2 into COPII vesicles, thus modulating the surface level of EphA2.Haeryung LeeHyuna NohJiyoung MunChangkyu GuSanja SeverSoochul ParkNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Haeryung Lee
Hyuna Noh
Jiyoung Mun
Changkyu Gu
Sanja Sever
Soochul Park
Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
description EphA2/ErbB2 complex is important in promoting breast cancer but the mechanism by which these receptor tyrosine kinases are exported from the endoplasmic reticulum is unknown. Here the authors show that Anks1a acts as a cargo adaptor in sorting EphA2 into COPII vesicles, thus modulating the surface level of EphA2.
format article
author Haeryung Lee
Hyuna Noh
Jiyoung Mun
Changkyu Gu
Sanja Sever
Soochul Park
author_facet Haeryung Lee
Hyuna Noh
Jiyoung Mun
Changkyu Gu
Sanja Sever
Soochul Park
author_sort Haeryung Lee
title Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
title_short Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
title_full Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
title_fullStr Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
title_full_unstemmed Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
title_sort anks1a regulates copii-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/414a168e7d8b4e848a820339ce79c82f
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AT jiyoungmun anks1aregulatescopiimediatedanterogradetransportofreceptortyrosinekinasescriticalfortumorigenesis
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