Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications

Biogenic polyamines (PAs) are involved in the growth and development of normal cells, and their intracellular concentration is stable. The concentration of PAs in cancer cells is significantly increased to promote and sustain their rapid proliferation. Over the years, synthetic PAs, which differ in...

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Autores principales:	Artemiy Nichugovskiy, Gian Cesare Tron, Mikhail Maslov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyamines polyamine conjugates antitumor activity antimalarial agents Ugi reaction Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/414c51bcd7124ffd8c640ef76c522c66
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spelling	oai:doaj.org-article:414c51bcd7124ffd8c640ef76c522c662021-11-11T18:33:28ZRecent Advances in the Synthesis of Polyamine Derivatives and Their Applications10.3390/molecules262165791420-3049https://doaj.org/article/414c51bcd7124ffd8c640ef76c522c662021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6579https://doaj.org/toc/1420-3049Biogenic polyamines (PAs) are involved in the growth and development of normal cells, and their intracellular concentration is stable. The concentration of PAs in cancer cells is significantly increased to promote and sustain their rapid proliferation. Over the years, synthetic PAs, which differ in their structure, have demonstrated high antitumor activity and are involved in clinical trials. The chemical synthesis of PAs and their conjugates require the correct choice of synthetic pathways—methods for constructing conjugates and the orthogonal protection of amino groups. The most common methods of synthesis of PA conjugates are acylation of regioselectively protected PAs or their alkylation under the conditions of the Fukuyama reaction. One of the most promising methods of PA synthesis is the use of a multicomponent Ugi reaction, which allows various PAs to be obtained in high yields. In this review, we describe and analyze various approaches that are used in the synthesis of polyamines and their conjugates.Artemiy NichugovskiyGian Cesare TronMikhail MaslovMDPI AGarticlepolyaminespolyamine conjugatesantitumor activityantimalarial agentsUgi reactionOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6579, p 6579 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyamines polyamine conjugates antitumor activity antimalarial agents Ugi reaction Organic chemistry QD241-441
spellingShingle	polyamines polyamine conjugates antitumor activity antimalarial agents Ugi reaction Organic chemistry QD241-441 Artemiy Nichugovskiy Gian Cesare Tron Mikhail Maslov Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
description	Biogenic polyamines (PAs) are involved in the growth and development of normal cells, and their intracellular concentration is stable. The concentration of PAs in cancer cells is significantly increased to promote and sustain their rapid proliferation. Over the years, synthetic PAs, which differ in their structure, have demonstrated high antitumor activity and are involved in clinical trials. The chemical synthesis of PAs and their conjugates require the correct choice of synthetic pathways—methods for constructing conjugates and the orthogonal protection of amino groups. The most common methods of synthesis of PA conjugates are acylation of regioselectively protected PAs or their alkylation under the conditions of the Fukuyama reaction. One of the most promising methods of PA synthesis is the use of a multicomponent Ugi reaction, which allows various PAs to be obtained in high yields. In this review, we describe and analyze various approaches that are used in the synthesis of polyamines and their conjugates.
format	article
author	Artemiy Nichugovskiy Gian Cesare Tron Mikhail Maslov
author_facet	Artemiy Nichugovskiy Gian Cesare Tron Mikhail Maslov
author_sort	Artemiy Nichugovskiy
title	Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
title_short	Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
title_full	Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
title_fullStr	Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
title_full_unstemmed	Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
title_sort	recent advances in the synthesis of polyamine derivatives and their applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/414c51bcd7124ffd8c640ef76c522c66
work_keys_str_mv	AT artemiynichugovskiy recentadvancesinthesynthesisofpolyaminederivativesandtheirapplications AT giancesaretron recentadvancesinthesynthesisofpolyaminederivativesandtheirapplications AT mikhailmaslov recentadvancesinthesynthesisofpolyaminederivativesandtheirapplications
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Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications

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