Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Abstract The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s disease (PD) symptomatology and pathophysiology. PD is often preceded by gastrointestinal symptoms and alterations of the enteric nervous...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefano Romano, George M. Savva, Janis R. Bedarf, Ian G. Charles, Falk Hildebrand, Arjan Narbad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/414d89f79c74448194e85eb8760f876e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:414d89f79c74448194e85eb8760f876e
record_format	dspace
spelling	oai:doaj.org-article:414d89f79c74448194e85eb8760f876e2021-12-02T13:34:53ZMeta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation10.1038/s41531-021-00156-z2373-8057https://doaj.org/article/414d89f79c74448194e85eb8760f876e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00156-zhttps://doaj.org/toc/2373-8057Abstract The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s disease (PD) symptomatology and pathophysiology. PD is often preceded by gastrointestinal symptoms and alterations of the enteric nervous system accompany the disease. Several studies have analyzed the gut microbiome in PD, but a consensus on the features of the PD-specific microbiota is missing. Here, we conduct a meta-analysis re-analyzing the ten currently available 16S microbiome datasets to investigate whether common alterations in the gut microbiota of PD patients exist across cohorts. We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as the most consistent PD gut microbiome alterations. This dysbiosis might result in a pro-inflammatory status which could be linked to the recurrent gastrointestinal symptoms affecting PD patients.Stefano RomanoGeorge M. SavvaJanis R. BedarfIan G. CharlesFalk HildebrandArjan NarbadNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Stefano Romano George M. Savva Janis R. Bedarf Ian G. Charles Falk Hildebrand Arjan Narbad Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
description	Abstract The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s disease (PD) symptomatology and pathophysiology. PD is often preceded by gastrointestinal symptoms and alterations of the enteric nervous system accompany the disease. Several studies have analyzed the gut microbiome in PD, but a consensus on the features of the PD-specific microbiota is missing. Here, we conduct a meta-analysis re-analyzing the ten currently available 16S microbiome datasets to investigate whether common alterations in the gut microbiota of PD patients exist across cohorts. We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as the most consistent PD gut microbiome alterations. This dysbiosis might result in a pro-inflammatory status which could be linked to the recurrent gastrointestinal symptoms affecting PD patients.
format	article
author	Stefano Romano George M. Savva Janis R. Bedarf Ian G. Charles Falk Hildebrand Arjan Narbad
author_facet	Stefano Romano George M. Savva Janis R. Bedarf Ian G. Charles Falk Hildebrand Arjan Narbad
author_sort	Stefano Romano
title	Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
title_short	Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
title_full	Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
title_fullStr	Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
title_full_unstemmed	Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
title_sort	meta-analysis of the parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/414d89f79c74448194e85eb8760f876e
work_keys_str_mv	AT stefanoromano metaanalysisoftheparkinsonsdiseasegutmicrobiomesuggestsalterationslinkedtointestinalinflammation AT georgemsavva metaanalysisoftheparkinsonsdiseasegutmicrobiomesuggestsalterationslinkedtointestinalinflammation AT janisrbedarf metaanalysisoftheparkinsonsdiseasegutmicrobiomesuggestsalterationslinkedtointestinalinflammation AT iangcharles metaanalysisoftheparkinsonsdiseasegutmicrobiomesuggestsalterationslinkedtointestinalinflammation AT falkhildebrand metaanalysisoftheparkinsonsdiseasegutmicrobiomesuggestsalterationslinkedtointestinalinflammation AT arjannarbad metaanalysisoftheparkinsonsdiseasegutmicrobiomesuggestsalterationslinkedtointestinalinflammation
_version_	1718392730549223424

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Ejemplares similares