Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea

Abstract The prevalence of diabetes during pregnancy and the need for the treatment are increasing. We aimed to investigate antidiabetic medications (ADM) use among pregnant women and their characteristics. Using Korea’s nationwide healthcare database, we included women aged 15–49 years with births...

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Autores principales:	Yunha Noh, Seung-Ah Choe, Ju-Young Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/414f49a157fc4aee9bc7e5bdcf4895b1
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spelling	oai:doaj.org-article:414f49a157fc4aee9bc7e5bdcf4895b12021-12-02T10:54:06ZTrends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea10.1038/s41598-021-83808-72045-2322https://doaj.org/article/414f49a157fc4aee9bc7e5bdcf4895b12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83808-7https://doaj.org/toc/2045-2322Abstract The prevalence of diabetes during pregnancy and the need for the treatment are increasing. We aimed to investigate antidiabetic medications (ADM) use among pregnant women and their characteristics. Using Korea’s nationwide healthcare database, we included women aged 15–49 years with births during 2004–2013. The prevalence and secular trend of ADM use were assessed in 3 periods: pre-conception period, first trimester, and second/third trimesters. To compare maternal characteristics between pregnancies with and without ADM prescription, we used the χ2 or Fisher’s exact test and Cochran-Armitage trend test. The prescription patterns analyzed by calendar year, age, insurance type, income, area, and medical institution. Of 81,559 pregnancies, 222 (0.27%) and 305 (0.37%) were exposed ADM during pre-conception and pregnancy periods, respectively. ADM prescriptions increased significantly by an 11.3-fold in second/third trimesters, while a 2.9-fold in first trimester. ADM use is more prevalent in women aged older and living in urban areas. Metformin was most used in the pre-conception period, while insulins were most during pregnancy. About 0.4% of women received ADM during pregnancy; a rate was lower than that in western countries. Non-recommended medications were more common in first trimester, which warrants pregnancy screening for women taking ADM.Yunha NohSeung-Ah ChoeJu-Young ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yunha Noh Seung-Ah Choe Ju-Young Shin Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea
description	Abstract The prevalence of diabetes during pregnancy and the need for the treatment are increasing. We aimed to investigate antidiabetic medications (ADM) use among pregnant women and their characteristics. Using Korea’s nationwide healthcare database, we included women aged 15–49 years with births during 2004–2013. The prevalence and secular trend of ADM use were assessed in 3 periods: pre-conception period, first trimester, and second/third trimesters. To compare maternal characteristics between pregnancies with and without ADM prescription, we used the χ2 or Fisher’s exact test and Cochran-Armitage trend test. The prescription patterns analyzed by calendar year, age, insurance type, income, area, and medical institution. Of 81,559 pregnancies, 222 (0.27%) and 305 (0.37%) were exposed ADM during pre-conception and pregnancy periods, respectively. ADM prescriptions increased significantly by an 11.3-fold in second/third trimesters, while a 2.9-fold in first trimester. ADM use is more prevalent in women aged older and living in urban areas. Metformin was most used in the pre-conception period, while insulins were most during pregnancy. About 0.4% of women received ADM during pregnancy; a rate was lower than that in western countries. Non-recommended medications were more common in first trimester, which warrants pregnancy screening for women taking ADM.
format	article
author	Yunha Noh Seung-Ah Choe Ju-Young Shin
author_facet	Yunha Noh Seung-Ah Choe Ju-Young Shin
author_sort	Yunha Noh
title	Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea
title_short	Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea
title_full	Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea
title_fullStr	Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea
title_full_unstemmed	Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea
title_sort	trends and associated maternal characteristics of antidiabetic medication use among pregnant women in south korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/414f49a157fc4aee9bc7e5bdcf4895b1
work_keys_str_mv	AT yunhanoh trendsandassociatedmaternalcharacteristicsofantidiabeticmedicationuseamongpregnantwomeninsouthkorea AT seungahchoe trendsandassociatedmaternalcharacteristicsofantidiabeticmedicationuseamongpregnantwomeninsouthkorea AT juyoungshin trendsandassociatedmaternalcharacteristicsofantidiabeticmedicationuseamongpregnantwomeninsouthkorea
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Trends and associated maternal characteristics of antidiabetic medication use among pregnant women in South Korea

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