Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

IRE1α is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1α, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo....

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Autores principales:	Decha Pinkaew, Abhijnan Chattopadhyay, Matthew D. King, Preedakorn Chunhacha, Zhihe Liu, Heather L. Stevenson, Yanjie Chen, Patuma Sinthujaroen, Owen M. McDougal, Ken Fujise
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41562ffacfaf46d09359e93528290463
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spelling	oai:doaj.org-article:41562ffacfaf46d09359e935282904632021-12-02T14:16:55ZFortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death10.1038/s41467-017-00029-12041-1723https://doaj.org/article/41562ffacfaf46d09359e935282904632017-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00029-1https://doaj.org/toc/2041-1723IRE1α is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1α, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo.Decha PinkaewAbhijnan ChattopadhyayMatthew D. KingPreedakorn ChunhachaZhihe LiuHeather L. StevensonYanjie ChenPatuma SinthujaroenOwen M. McDougalKen FujiseNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Decha Pinkaew Abhijnan Chattopadhyay Matthew D. King Preedakorn Chunhacha Zhihe Liu Heather L. Stevenson Yanjie Chen Patuma Sinthujaroen Owen M. McDougal Ken Fujise Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
description	IRE1α is an ER stress sensor, whose activity induces apoptosis. Here, the authors report that fortilin, a pro-survival factor, with yet unknown roles in ER stress, interacts with active IRE1α, inhibits both its kinase end RNase activities, and protects cells from apoptosis both in vitro and in vivo.
format	article
author	Decha Pinkaew Abhijnan Chattopadhyay Matthew D. King Preedakorn Chunhacha Zhihe Liu Heather L. Stevenson Yanjie Chen Patuma Sinthujaroen Owen M. McDougal Ken Fujise
author_facet	Decha Pinkaew Abhijnan Chattopadhyay Matthew D. King Preedakorn Chunhacha Zhihe Liu Heather L. Stevenson Yanjie Chen Patuma Sinthujaroen Owen M. McDougal Ken Fujise
author_sort	Decha Pinkaew
title	Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
title_short	Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
title_full	Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
title_fullStr	Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
title_full_unstemmed	Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
title_sort	fortilin binds ire1α and prevents er stress from signaling apoptotic cell death
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/41562ffacfaf46d09359e93528290463
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Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

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