Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients

Aim of the work: To describe musculoskeletal ultrasound (MSUS) findings in patients with systemic sclerosis (SSc) and to study their relation with cardiopulmonary and skin affection. Patient and methods: In 50 SSc patients, hands, wrists and six entheses sites were evaluated by MSUS. Entheses were s...

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Autores principales:	Hala I. Elgendy, Mohammed Y. Ezzeldin, Yumn A. Elsabagh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Systemic sclerosis Ultrasonography Cardiopulmonary Skin Arthritis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4156583cd96e414ea2aebb9413ad3563
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spelling	oai:doaj.org-article:4156583cd96e414ea2aebb9413ad35632021-11-12T04:27:08ZCharacteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients1110-116410.1016/j.ejr.2021.10.007https://doaj.org/article/4156583cd96e414ea2aebb9413ad35632022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1110116421000958https://doaj.org/toc/1110-1164Aim of the work: To describe musculoskeletal ultrasound (MSUS) findings in patients with systemic sclerosis (SSc) and to study their relation with cardiopulmonary and skin affection. Patient and methods: In 50 SSc patients, hands, wrists and six entheses sites were evaluated by MSUS. Entheses were scored using the Madrid Sonography Enthesitis Index (MASEI). The modified Rodnan skin score (mRSS) was assessed. Results: They were 42 females/8males with a mean age 36.2 ± 11.6 years, disease duration 3.5 ± 4.2 years, 27 had limited skin affection and 23 diffuse and the mRSS was 4.1 ± 15.3. 54% had arthritis, 10% tendon friction rub, 16% joint contractures and 10% calcinosis. 18% had left ventricular hypertrophy, 34% had pulmonary hypertension, 20% had restrictive pulmonary function test (PFT) and 24% had interstial lung disease (ILD). Synovitis was detected in 58% and was significantly related to mRSS, left ventricular hypertrophy, PFT, pulmonary hypertension and ILD (p = 0.023, p = 0.03, p = 0.006, p = 0.026 and p = 0.039 respectively). Common extensor tenosynovitis was detected in 82% and was significantly related to mRSS, PFT and ILD (p = 0.019, p = 0.043 and p = 0.032 respectively). Joint erosions were detected in 36% and were significantly related to age and C-reactive protein (CRP) (p = 0.01 and p = 0.034). Enthesopathy showed a significant relation with erythrocyte sedimentation rate (ESR), CRP and mRSS (p = 0.014, p = 0.013, p = 0.025, respectively). Conclusion: Articular involvement is common in SSc and underestimated by clinical examination. Synovitis is associated with cardiovascular complication in SSc. Tenosynovitis is clinically related to restrictive pulmonary function. Enthesopathy should be kept in mind in symptomatic patients with systemic sclerosis.Hala I. ElgendyMohammed Y. EzzeldinYumn A. ElsabaghElsevierarticleSystemic sclerosisUltrasonographyCardiopulmonarySkinArthritisImmunologic diseases. AllergyRC581-607ENEgyptian Rheumatologist, Vol 44, Iss 2, Pp 133-138 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Systemic sclerosis Ultrasonography Cardiopulmonary Skin Arthritis Immunologic diseases. Allergy RC581-607
spellingShingle	Systemic sclerosis Ultrasonography Cardiopulmonary Skin Arthritis Immunologic diseases. Allergy RC581-607 Hala I. Elgendy Mohammed Y. Ezzeldin Yumn A. Elsabagh Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
description	Aim of the work: To describe musculoskeletal ultrasound (MSUS) findings in patients with systemic sclerosis (SSc) and to study their relation with cardiopulmonary and skin affection. Patient and methods: In 50 SSc patients, hands, wrists and six entheses sites were evaluated by MSUS. Entheses were scored using the Madrid Sonography Enthesitis Index (MASEI). The modified Rodnan skin score (mRSS) was assessed. Results: They were 42 females/8males with a mean age 36.2 ± 11.6 years, disease duration 3.5 ± 4.2 years, 27 had limited skin affection and 23 diffuse and the mRSS was 4.1 ± 15.3. 54% had arthritis, 10% tendon friction rub, 16% joint contractures and 10% calcinosis. 18% had left ventricular hypertrophy, 34% had pulmonary hypertension, 20% had restrictive pulmonary function test (PFT) and 24% had interstial lung disease (ILD). Synovitis was detected in 58% and was significantly related to mRSS, left ventricular hypertrophy, PFT, pulmonary hypertension and ILD (p = 0.023, p = 0.03, p = 0.006, p = 0.026 and p = 0.039 respectively). Common extensor tenosynovitis was detected in 82% and was significantly related to mRSS, PFT and ILD (p = 0.019, p = 0.043 and p = 0.032 respectively). Joint erosions were detected in 36% and were significantly related to age and C-reactive protein (CRP) (p = 0.01 and p = 0.034). Enthesopathy showed a significant relation with erythrocyte sedimentation rate (ESR), CRP and mRSS (p = 0.014, p = 0.013, p = 0.025, respectively). Conclusion: Articular involvement is common in SSc and underestimated by clinical examination. Synovitis is associated with cardiovascular complication in SSc. Tenosynovitis is clinically related to restrictive pulmonary function. Enthesopathy should be kept in mind in symptomatic patients with systemic sclerosis.
format	article
author	Hala I. Elgendy Mohammed Y. Ezzeldin Yumn A. Elsabagh
author_facet	Hala I. Elgendy Mohammed Y. Ezzeldin Yumn A. Elsabagh
author_sort	Hala I. Elgendy
title	Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
title_short	Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
title_full	Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
title_fullStr	Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
title_full_unstemmed	Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
title_sort	characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/4156583cd96e414ea2aebb9413ad3563
work_keys_str_mv	AT halaielgendy characteristicsofmusculoskeletalultrasoundanditsrelationshipwithsystemicinflammationinsystemicsclerosispatients AT mohammedyezzeldin characteristicsofmusculoskeletalultrasoundanditsrelationshipwithsystemicinflammationinsystemicsclerosispatients AT yumnaelsabagh characteristicsofmusculoskeletalultrasoundanditsrelationshipwithsystemicinflammationinsystemicsclerosispatients
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Characteristics of musculoskeletal ultrasound and its relationship with systemic inflammation in systemic sclerosis patients

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