DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.

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Autores principales:	Kin Man Suen, Fabian Braukmann, Richard Butler, Dalila Bensaddek, Alper Akay, Chi-Chuan Lin, Dovilė Milonaitytė, Neel Doshi, Alexandra Sapetschnig, Angus Lamond, John Edward Ladbury, Eric Alexander Miska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41574a0478304ed5b2da4e86531e0f12
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spelling	oai:doaj.org-article:41574a0478304ed5b2da4e86531e0f122021-12-02T15:09:26ZDEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans10.1038/s41467-020-18089-12041-1723https://doaj.org/article/41574a0478304ed5b2da4e86531e0f122020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18089-1https://doaj.org/toc/2041-1723The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.Kin Man SuenFabian BraukmannRichard ButlerDalila BensaddekAlper AkayChi-Chuan LinDovilė MilonaitytėNeel DoshiAlexandra SapetschnigAngus LamondJohn Edward LadburyEric Alexander MiskaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kin Man Suen Fabian Braukmann Richard Butler Dalila Bensaddek Alper Akay Chi-Chuan Lin Dovilė Milonaitytė Neel Doshi Alexandra Sapetschnig Angus Lamond John Edward Ladbury Eric Alexander Miska DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
description	The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.
format	article
author	Kin Man Suen Fabian Braukmann Richard Butler Dalila Bensaddek Alper Akay Chi-Chuan Lin Dovilė Milonaitytė Neel Doshi Alexandra Sapetschnig Angus Lamond John Edward Ladbury Eric Alexander Miska
author_facet	Kin Man Suen Fabian Braukmann Richard Butler Dalila Bensaddek Alper Akay Chi-Chuan Lin Dovilė Milonaitytė Neel Doshi Alexandra Sapetschnig Angus Lamond John Edward Ladbury Eric Alexander Miska
author_sort	Kin Man Suen
title	DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
title_short	DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
title_full	DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
title_fullStr	DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
title_full_unstemmed	DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
title_sort	deps-1 is required for pirna-dependent silencing and piwi condensate organisation in caenorhabditis elegans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/41574a0478304ed5b2da4e86531e0f12
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DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

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