Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches

ABSTRACT A grand challenge in microbiology is to understand how the dormant majority lives. In natural environments, most microorganisms are not growing and instead exist in a spectrum of dormant states. Despite this, most research on microbial metabolism continues to be growth-centric, and many ove...

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Autores principales:	Chris Greening, Rhys Grinter, Eleonora Chiri
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	hydrogen metabolism mycobacteria persistence soil microbiology trace gases Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/415774978f514f0d917afa5f956759fe
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spelling	oai:doaj.org-article:415774978f514f0d917afa5f956759fe2021-12-02T19:47:35ZUncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches10.1128/mSystems.00107-192379-5077https://doaj.org/article/415774978f514f0d917afa5f956759fe2019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00107-19https://doaj.org/toc/2379-5077ABSTRACT A grand challenge in microbiology is to understand how the dormant majority lives. In natural environments, most microorganisms are not growing and instead exist in a spectrum of dormant states. Despite this, most research on microbial metabolism continues to be growth-centric, and many overlook the fact that dormant cells require energy for maintenance. In this perspective, we discuss our research program to uncover the metabolic strategies that support microbial survival. We present two major principles underlying these studies. The first is the recent realization that microbial survival depends on previously unrecognized metabolic flexibility. The second is that new discoveries in this area depend on more sophisticated integration of approaches at the molecular, cellular, and ecosystem levels. These principles are illustrated with examples from the literature, including our own work demonstrating that bacteria can live on air, and areas for future methodological and theoretical development are highlighted.Chris GreeningRhys GrinterEleonora ChiriAmerican Society for Microbiologyarticlehydrogenmetabolismmycobacteriapersistencesoil microbiologytrace gasesMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrogen metabolism mycobacteria persistence soil microbiology trace gases Microbiology QR1-502
spellingShingle	hydrogen metabolism mycobacteria persistence soil microbiology trace gases Microbiology QR1-502 Chris Greening Rhys Grinter Eleonora Chiri Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches
description	ABSTRACT A grand challenge in microbiology is to understand how the dormant majority lives. In natural environments, most microorganisms are not growing and instead exist in a spectrum of dormant states. Despite this, most research on microbial metabolism continues to be growth-centric, and many overlook the fact that dormant cells require energy for maintenance. In this perspective, we discuss our research program to uncover the metabolic strategies that support microbial survival. We present two major principles underlying these studies. The first is the recent realization that microbial survival depends on previously unrecognized metabolic flexibility. The second is that new discoveries in this area depend on more sophisticated integration of approaches at the molecular, cellular, and ecosystem levels. These principles are illustrated with examples from the literature, including our own work demonstrating that bacteria can live on air, and areas for future methodological and theoretical development are highlighted.
format	article
author	Chris Greening Rhys Grinter Eleonora Chiri
author_facet	Chris Greening Rhys Grinter Eleonora Chiri
author_sort	Chris Greening
title	Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches
title_short	Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches
title_full	Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches
title_fullStr	Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches
title_full_unstemmed	Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches
title_sort	uncovering the metabolic strategies of the dormant microbial majority: towards integrative approaches
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/415774978f514f0d917afa5f956759fe
work_keys_str_mv	AT chrisgreening uncoveringthemetabolicstrategiesofthedormantmicrobialmajoritytowardsintegrativeapproaches AT rhysgrinter uncoveringthemetabolicstrategiesofthedormantmicrobialmajoritytowardsintegrativeapproaches AT eleonorachiri uncoveringthemetabolicstrategiesofthedormantmicrobialmajoritytowardsintegrativeapproaches
_version_	1718375955644284928

Uncovering the Metabolic Strategies of the Dormant Microbial Majority: towards Integrative Approaches

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