Drug-utilisation profiles and COVID-19

Abstract Coronavirus disease 2019 (COVID-19) has substantially challenged healthcare systems worldwide. By investigating population characteristics and prescribing profiles, it is possible to generate hypotheses about the associations between specific drug-utilisation profiles and susceptibility to...

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Autores principales:	Valentina Orlando, Enrico Coscioni, Ilaria Guarino, Sara Mucherino, Alessandro Perrella, Ugo Trama, Giuseppe Limongelli, Enrica Menditto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41587489ae0a44ffbcd903a5dbe8c718
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spelling	oai:doaj.org-article:41587489ae0a44ffbcd903a5dbe8c7182021-12-02T16:56:10ZDrug-utilisation profiles and COVID-1910.1038/s41598-021-88398-y2045-2322https://doaj.org/article/41587489ae0a44ffbcd903a5dbe8c7182021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88398-yhttps://doaj.org/toc/2045-2322Abstract Coronavirus disease 2019 (COVID-19) has substantially challenged healthcare systems worldwide. By investigating population characteristics and prescribing profiles, it is possible to generate hypotheses about the associations between specific drug-utilisation profiles and susceptibility to COVID-19 infection. A retrospective drug-utilisation study was carried out using routinely collected information from a healthcare database in Campania (Southern Italy). We aimed to discover the prevalence of drug utilisation (monotherapy and polytherapy) in COVID-19 versus non-COVID-19 patients in Campania (~ 6 million inhabitants). The study cohort comprised 1532 individuals who tested positive for COVID-19. Drugs were grouped according to the Anatomical Therapeutic Chemical (ATC) classification system. We noted higher prevalence rates of the use of drugs in the ATC categories C01, B01 and M04, which was probably linked to related comorbidities (i.e., cardiovascular and metabolic). Nevertheless, the prevalence of the use of drugs acting on the renin-angiotensin system, such as antihypertensive drugs, was not higher in COVID-19 patients than in non-COVID-19 patients after adjustments for age and sex. These results highlight the need for further case–control studies to define the effects of medications and comorbidities on susceptibility to and associated mortality from COVID-19.Valentina OrlandoEnrico CoscioniIlaria GuarinoSara MucherinoAlessandro PerrellaUgo TramaGiuseppe LimongelliEnrica MendittoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valentina Orlando Enrico Coscioni Ilaria Guarino Sara Mucherino Alessandro Perrella Ugo Trama Giuseppe Limongelli Enrica Menditto Drug-utilisation profiles and COVID-19
description	Abstract Coronavirus disease 2019 (COVID-19) has substantially challenged healthcare systems worldwide. By investigating population characteristics and prescribing profiles, it is possible to generate hypotheses about the associations between specific drug-utilisation profiles and susceptibility to COVID-19 infection. A retrospective drug-utilisation study was carried out using routinely collected information from a healthcare database in Campania (Southern Italy). We aimed to discover the prevalence of drug utilisation (monotherapy and polytherapy) in COVID-19 versus non-COVID-19 patients in Campania (~ 6 million inhabitants). The study cohort comprised 1532 individuals who tested positive for COVID-19. Drugs were grouped according to the Anatomical Therapeutic Chemical (ATC) classification system. We noted higher prevalence rates of the use of drugs in the ATC categories C01, B01 and M04, which was probably linked to related comorbidities (i.e., cardiovascular and metabolic). Nevertheless, the prevalence of the use of drugs acting on the renin-angiotensin system, such as antihypertensive drugs, was not higher in COVID-19 patients than in non-COVID-19 patients after adjustments for age and sex. These results highlight the need for further case–control studies to define the effects of medications and comorbidities on susceptibility to and associated mortality from COVID-19.
format	article
author	Valentina Orlando Enrico Coscioni Ilaria Guarino Sara Mucherino Alessandro Perrella Ugo Trama Giuseppe Limongelli Enrica Menditto
author_facet	Valentina Orlando Enrico Coscioni Ilaria Guarino Sara Mucherino Alessandro Perrella Ugo Trama Giuseppe Limongelli Enrica Menditto
author_sort	Valentina Orlando
title	Drug-utilisation profiles and COVID-19
title_short	Drug-utilisation profiles and COVID-19
title_full	Drug-utilisation profiles and COVID-19
title_fullStr	Drug-utilisation profiles and COVID-19
title_full_unstemmed	Drug-utilisation profiles and COVID-19
title_sort	drug-utilisation profiles and covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41587489ae0a44ffbcd903a5dbe8c718
work_keys_str_mv	AT valentinaorlando drugutilisationprofilesandcovid19 AT enricocoscioni drugutilisationprofilesandcovid19 AT ilariaguarino drugutilisationprofilesandcovid19 AT saramucherino drugutilisationprofilesandcovid19 AT alessandroperrella drugutilisationprofilesandcovid19 AT ugotrama drugutilisationprofilesandcovid19 AT giuseppelimongelli drugutilisationprofilesandcovid19 AT enricamenditto drugutilisationprofilesandcovid19
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Drug-utilisation profiles and COVID-19

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