Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits

This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal...

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Autores principales:	Omnia S. Farrag, Doaa Salman, Fatma Abo Zakaib Ali, Arafat S. Sayed, Motamed E. Mahmoud, Abd-El Raheem A Abd-El Raheem
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2020
Materias:	propylthiouracil put rabbits renal dysfunction Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2020.85584 https://doaj.org/article/415874cf892445eab7eb6562079c5b85
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spelling	oai:doaj.org-article:415874cf892445eab7eb6562079c5b852021-12-02T11:43:52ZImpact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbitshttps://dx.doi.org/10.21608/javs.2020.855841687-40722090-3308https://doaj.org/article/415874cf892445eab7eb6562079c5b852020-04-01T00:00:00Zhttps://javs.journals.ekb.eg/article_85584.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T3 and T4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits. Omnia S. FarragDoaa SalmanFatma Abo Zakaib AliArafat S. SayedMotamed E. MahmoudAbd-El Raheem A Abd-El RaheemEgyptian Society for Animal Managementarticlepropylthiouracilputrabbitsrenal dysfunctionZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 5, Iss 2, Pp 49-60 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	propylthiouracil put rabbits renal dysfunction Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	propylthiouracil put rabbits renal dysfunction Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Omnia S. Farrag Doaa Salman Fatma Abo Zakaib Ali Arafat S. Sayed Motamed E. Mahmoud Abd-El Raheem A Abd-El Raheem Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
description	This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T3 and T4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits.
format	article
author	Omnia S. Farrag Doaa Salman Fatma Abo Zakaib Ali Arafat S. Sayed Motamed E. Mahmoud Abd-El Raheem A Abd-El Raheem
author_facet	Omnia S. Farrag Doaa Salman Fatma Abo Zakaib Ali Arafat S. Sayed Motamed E. Mahmoud Abd-El Raheem A Abd-El Raheem
author_sort	Omnia S. Farrag
title	Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
title_short	Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
title_full	Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
title_fullStr	Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
title_full_unstemmed	Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
title_sort	impact of continuous treatment with propylthiouracil on renal and hepatic functions in rabbits
publisher	Egyptian Society for Animal Management
publishDate	2020
url	https://dx.doi.org/10.21608/javs.2020.85584 https://doaj.org/article/415874cf892445eab7eb6562079c5b85
work_keys_str_mv	AT omniasfarrag impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT doaasalman impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT fatmaabozakaibali impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT arafatssayed impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT motamedemahmoud impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT abdelraheemaabdelraheem impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits
_version_	1718395336582496256

Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits

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