Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death

Apoptosis is a cellular process that eliminates damaged or superfluous cells. Here the authors show that cells undergoing apoptotic stresss secrete the growth factor FGF2, which upregulates pro-survival BCL-2 proteins in neighbouring cells, thereby promoting their survival.

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Autores principales:	Florian J. Bock, Egor Sedov, Elle Koren, Anna L. Koessinger, Catherine Cloix, Désirée Zerbst, Dimitris Athineos, Jayanthi Anand, Kirsteen J. Campbell, Karen Blyth, Yaron Fuchs, Stephen W. G. Tait
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/415af44f66154f70b3f34ec84435ad64
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spelling	oai:doaj.org-article:415af44f66154f70b3f34ec84435ad642021-11-14T12:36:41ZApoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death10.1038/s41467-021-26613-02041-1723https://doaj.org/article/415af44f66154f70b3f34ec84435ad642021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26613-0https://doaj.org/toc/2041-1723Apoptosis is a cellular process that eliminates damaged or superfluous cells. Here the authors show that cells undergoing apoptotic stresss secrete the growth factor FGF2, which upregulates pro-survival BCL-2 proteins in neighbouring cells, thereby promoting their survival.Florian J. BockEgor SedovElle KorenAnna L. KoessingerCatherine CloixDésirée ZerbstDimitris AthineosJayanthi AnandKirsteen J. CampbellKaren BlythYaron FuchsStephen W. G. TaitNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian J. Bock Egor Sedov Elle Koren Anna L. Koessinger Catherine Cloix Désirée Zerbst Dimitris Athineos Jayanthi Anand Kirsteen J. Campbell Karen Blyth Yaron Fuchs Stephen W. G. Tait Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
description	Apoptosis is a cellular process that eliminates damaged or superfluous cells. Here the authors show that cells undergoing apoptotic stresss secrete the growth factor FGF2, which upregulates pro-survival BCL-2 proteins in neighbouring cells, thereby promoting their survival.
format	article
author	Florian J. Bock Egor Sedov Elle Koren Anna L. Koessinger Catherine Cloix Désirée Zerbst Dimitris Athineos Jayanthi Anand Kirsteen J. Campbell Karen Blyth Yaron Fuchs Stephen W. G. Tait
author_facet	Florian J. Bock Egor Sedov Elle Koren Anna L. Koessinger Catherine Cloix Désirée Zerbst Dimitris Athineos Jayanthi Anand Kirsteen J. Campbell Karen Blyth Yaron Fuchs Stephen W. G. Tait
author_sort	Florian J. Bock
title	Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
title_short	Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
title_full	Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
title_fullStr	Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
title_full_unstemmed	Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death
title_sort	apoptotic stress-induced fgf signalling promotes non-cell autonomous resistance to cell death
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/415af44f66154f70b3f34ec84435ad64
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Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death

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