Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

Here, using a repeat-exposure penile SHIV infection model in macaques, the authors show that a single subcutaneous administration of a broadly neutralizing antibody (bNAb) exerts long-acting protection against both penile and vaginal virus exposure, which highlights bNAbs as a potential therapeutic...

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Autores principales:	David A. Garber, Debra R. Adams, Patricia Guenthner, James Mitchell, Kristen Kelley, Till Schoofs, Anna Gazumyan, Martha Nason, Michael S. Seaman, Janet McNicholl, Michel C. Nussenzweig, Walid Heneine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/415ea2495b55415ba7d408c549af42a5
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spelling	oai:doaj.org-article:415ea2495b55415ba7d408c549af42a52021-12-02T16:06:03ZDurable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies10.1038/s41467-020-16928-92041-1723https://doaj.org/article/415ea2495b55415ba7d408c549af42a52020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16928-9https://doaj.org/toc/2041-1723Here, using a repeat-exposure penile SHIV infection model in macaques, the authors show that a single subcutaneous administration of a broadly neutralizing antibody (bNAb) exerts long-acting protection against both penile and vaginal virus exposure, which highlights bNAbs as a potential therapeutic for LA-PrEP.David A. GarberDebra R. AdamsPatricia GuenthnerJames MitchellKristen KelleyTill SchoofsAnna GazumyanMartha NasonMichael S. SeamanJanet McNichollMichel C. NussenzweigWalid HeneineNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David A. Garber Debra R. Adams Patricia Guenthner James Mitchell Kristen Kelley Till Schoofs Anna Gazumyan Martha Nason Michael S. Seaman Janet McNicholl Michel C. Nussenzweig Walid Heneine Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
description	Here, using a repeat-exposure penile SHIV infection model in macaques, the authors show that a single subcutaneous administration of a broadly neutralizing antibody (bNAb) exerts long-acting protection against both penile and vaginal virus exposure, which highlights bNAbs as a potential therapeutic for LA-PrEP.
format	article
author	David A. Garber Debra R. Adams Patricia Guenthner James Mitchell Kristen Kelley Till Schoofs Anna Gazumyan Martha Nason Michael S. Seaman Janet McNicholl Michel C. Nussenzweig Walid Heneine
author_facet	David A. Garber Debra R. Adams Patricia Guenthner James Mitchell Kristen Kelley Till Schoofs Anna Gazumyan Martha Nason Michael S. Seaman Janet McNicholl Michel C. Nussenzweig Walid Heneine
author_sort	David A. Garber
title	Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
title_short	Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
title_full	Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
title_fullStr	Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
title_full_unstemmed	Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
title_sort	durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/415ea2495b55415ba7d408c549af42a5
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Durable protection against repeated penile exposures to simian-human immunodeficiency virus by broadly neutralizing antibodies

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