Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydroph...

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Autores principales:	Teresa B. V. Dinis, Francisca A. e Silva, Fani Sousa, Mara G. Freire
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	active pharmaceutical ingredients solubility concentration bioavailability aqueous biphasic systems ionic liquids Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/415efc259aec40aab6bb45b484f71dad
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spelling	oai:doaj.org-article:415efc259aec40aab6bb45b484f71dad2021-11-11T17:49:13ZAdvances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals10.3390/ma142162311996-1944https://doaj.org/article/415efc259aec40aab6bb45b484f71dad2021-10-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6231https://doaj.org/toc/1996-1944The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs’ aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided.Teresa B. V. DinisFrancisca A. e SilvaFani SousaMara G. FreireMDPI AGarticleactive pharmaceutical ingredientssolubilityconcentrationbioavailabilityaqueous biphasic systemsionic liquidsTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6231, p 6231 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	active pharmaceutical ingredients solubility concentration bioavailability aqueous biphasic systems ionic liquids Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	active pharmaceutical ingredients solubility concentration bioavailability aqueous biphasic systems ionic liquids Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Teresa B. V. Dinis Francisca A. e Silva Fani Sousa Mara G. Freire Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
description	The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs’ aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided.
format	article
author	Teresa B. V. Dinis Francisca A. e Silva Fani Sousa Mara G. Freire
author_facet	Teresa B. V. Dinis Francisca A. e Silva Fani Sousa Mara G. Freire
author_sort	Teresa B. V. Dinis
title	Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
title_short	Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
title_full	Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
title_fullStr	Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
title_full_unstemmed	Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals
title_sort	advances brought by hydrophilic ionic liquids in fields involving pharmaceuticals
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/415efc259aec40aab6bb45b484f71dad
work_keys_str_mv	AT teresabvdinis advancesbroughtbyhydrophilicionicliquidsinfieldsinvolvingpharmaceuticals AT franciscaaesilva advancesbroughtbyhydrophilicionicliquidsinfieldsinvolvingpharmaceuticals AT fanisousa advancesbroughtbyhydrophilicionicliquidsinfieldsinvolvingpharmaceuticals AT maragfreire advancesbroughtbyhydrophilicionicliquidsinfieldsinvolvingpharmaceuticals
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Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

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