Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system

Objective: We re-classified patients with stage IB–II disease (based on the 2008 system) and compared the outcomes with those obtained after using the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system. Materials and methods: We reviewed the data of 154 patients with ce...

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Autores principales:	Daiken Osaku, Hiroaki Komatsu, Masayo Okawa, Yuki Iida, Shinya Sato, Tetsuro Oishi, Tasuku Harada
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hysterectomy Lymph nodes Squamous cell carcinoma Uterine cervical cancer Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/4160a0165ddd4010965f39ef2bd86ab8
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spelling	oai:doaj.org-article:4160a0165ddd4010965f39ef2bd86ab82021-11-18T04:44:44ZRe-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system1028-455910.1016/j.tjog.2021.09.016https://doaj.org/article/4160a0165ddd4010965f39ef2bd86ab82021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002564https://doaj.org/toc/1028-4559Objective: We re-classified patients with stage IB–II disease (based on the 2008 system) and compared the outcomes with those obtained after using the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system. Materials and methods: We reviewed the data of 154 patients with cervical cancer who underwent radical hysterectomy at our hospital during 2006–2016. Pathological, histological, and radiographic data were used to re-classify the cases based on the 2018 FIGO system. We compared these outcomes to those obtained after using the 2008 FIGO assignments. Overall survival (OS) was calculated from primary therapy initiation until death or the last follow-up examination. Results: The histological types were squamous cell carcinoma (108 cases) and others (46 cases). The 2008 FIGO system assignments were stage IB1, IB2, IIA1, IIA2, and IIB (87, 27, seven, five, and 28 patients, respectively). The new 2018 FIGO system assignments were stage IB1, IB2, IB3, IIA1, IIA2, IIB, and IIIC1 (52, 26, 16, six, three, 21, and 30 patients, respectively). Re-classification to stage IIIC1 disease was observed for previously assigned stage IB1, IB2, IIA1, IIA2, and IIB cases (10, seven, two, two, and nine cases, respectively). The median OS durations based on the 2018 FIGO system were 71.7, 61.1, and 62.3 months for patients with stage IB1, IB2, and IB3 (p = 0.04) disease, respectively. The new stage IB3/IIA2/IIB cases had longer OS than the old stage IB2/IIA2/IIB cases. A positive computed tomography (CT) finding of nodal involvement was observed in 37% of cases with pathological confirmation of pelvic lymph node (LN) involvement. Using CT to identify pelvic LN metastasis had a sensitivity of 37% and specificity of 93%. Conclusion: The 2018 FIGO staging system for cervical cancer after radical hysterectomy showed a better ability to differentiate survival outcomes. However, the image evaluation method should be reconsidered.Daiken OsakuHiroaki KomatsuMasayo OkawaYuki IidaShinya SatoTetsuro OishiTasuku HaradaElsevierarticleHysterectomyLymph nodesSquamous cell carcinomaUterine cervical cancerGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1054-1058 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hysterectomy Lymph nodes Squamous cell carcinoma Uterine cervical cancer Gynecology and obstetrics RG1-991
spellingShingle	Hysterectomy Lymph nodes Squamous cell carcinoma Uterine cervical cancer Gynecology and obstetrics RG1-991 Daiken Osaku Hiroaki Komatsu Masayo Okawa Yuki Iida Shinya Sato Tetsuro Oishi Tasuku Harada Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system
description	Objective: We re-classified patients with stage IB–II disease (based on the 2008 system) and compared the outcomes with those obtained after using the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system. Materials and methods: We reviewed the data of 154 patients with cervical cancer who underwent radical hysterectomy at our hospital during 2006–2016. Pathological, histological, and radiographic data were used to re-classify the cases based on the 2018 FIGO system. We compared these outcomes to those obtained after using the 2008 FIGO assignments. Overall survival (OS) was calculated from primary therapy initiation until death or the last follow-up examination. Results: The histological types were squamous cell carcinoma (108 cases) and others (46 cases). The 2008 FIGO system assignments were stage IB1, IB2, IIA1, IIA2, and IIB (87, 27, seven, five, and 28 patients, respectively). The new 2018 FIGO system assignments were stage IB1, IB2, IB3, IIA1, IIA2, IIB, and IIIC1 (52, 26, 16, six, three, 21, and 30 patients, respectively). Re-classification to stage IIIC1 disease was observed for previously assigned stage IB1, IB2, IIA1, IIA2, and IIB cases (10, seven, two, two, and nine cases, respectively). The median OS durations based on the 2018 FIGO system were 71.7, 61.1, and 62.3 months for patients with stage IB1, IB2, and IB3 (p = 0.04) disease, respectively. The new stage IB3/IIA2/IIB cases had longer OS than the old stage IB2/IIA2/IIB cases. A positive computed tomography (CT) finding of nodal involvement was observed in 37% of cases with pathological confirmation of pelvic lymph node (LN) involvement. Using CT to identify pelvic LN metastasis had a sensitivity of 37% and specificity of 93%. Conclusion: The 2018 FIGO staging system for cervical cancer after radical hysterectomy showed a better ability to differentiate survival outcomes. However, the image evaluation method should be reconsidered.
format	article
author	Daiken Osaku Hiroaki Komatsu Masayo Okawa Yuki Iida Shinya Sato Tetsuro Oishi Tasuku Harada
author_facet	Daiken Osaku Hiroaki Komatsu Masayo Okawa Yuki Iida Shinya Sato Tetsuro Oishi Tasuku Harada
author_sort	Daiken Osaku
title	Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system
title_short	Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system
title_full	Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system
title_fullStr	Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system
title_full_unstemmed	Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system
title_sort	re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 figo staging system
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4160a0165ddd4010965f39ef2bd86ab8
work_keys_str_mv	AT daikenosaku reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem AT hiroakikomatsu reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem AT masayookawa reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem AT yukiiida reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem AT shinyasato reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem AT tetsurooishi reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem AT tasukuharada reclassificationofuterinecervicalcancercasestreatedwithradicalhysterectomybasedonthe2018figostagingsystem
_version_	1718425094331564032

Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system

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