A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort

Background: Exposure to metals lead (Pb), mercury (Hg), and cadmium (Cd) and trace elements selenium (Se) and manganese (Mn) has been linked to the developmental origins of cardiometabolic diseases, but the mechanisms are not well-understood. Objective: Conduct a metabolome-wide association study to...

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Autores principales:	Mingyu Zhang, Jessie P Buckley, Liming Liang, Xiumei Hong, Guoying Wang, Mei-Cheng Wang, Marsha Wills-Karp, Xiaobin Wang, Noel T Mueller
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Heavy metals Lead Mercury Cadmium Trace elements Selenium Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/416180a622c04bcbab9b582ed8e13c8e
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spelling	oai:doaj.org-article:416180a622c04bcbab9b582ed8e13c8e2021-11-20T04:55:40ZA metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort0160-412010.1016/j.envint.2021.106976https://doaj.org/article/416180a622c04bcbab9b582ed8e13c8e2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0160412021006012https://doaj.org/toc/0160-4120Background: Exposure to metals lead (Pb), mercury (Hg), and cadmium (Cd) and trace elements selenium (Se) and manganese (Mn) has been linked to the developmental origins of cardiometabolic diseases, but the mechanisms are not well-understood. Objective: Conduct a metabolome-wide association study to understand how in utero exposure to Pb, Hg, Cd, Se, and Mn affects the metabolic programming of fetuses. Methods: We used data from the Boston Birth Cohort, which enrolled mother-child pairs from Boston, MA. We measured metals and trace elements in maternal red blood cells (RBCs) collected 24–72 h after delivery, and metabolites in cord blood collected at birth. We used multivariable linear regression to examine associations of metals and trace elements with metabolites and Bonferroni correction to account for multiple comparisons. We assessed non-linear associations of metals and trace elements with metabolites using restricted cubic spline plots. Results: This analysis included 670 mother-child pairs (57% non-Hispanic Black and 24% Hispanic). After Bonferroni correction, there were 25 cord metabolites associated with at least one of the metals or trace elements. Pb was negatively associated with the xenobiotic piperine, Cd was positively associated with xenobiotics cotinine and hydroxycotinine, and Hg was associated with 8 lipid metabolites (in both directions). Se and Mn shared associations with 6 metabolites (in both directions), which mostly included nucleotides and amino acids; Se was additionally associated with 7 metabolites (mostly amino acids, nucleotides, and carnitines) and Mn was additionally associated with C36:4 hydroxy phosphatidylcholine. Restricted cubic spline plots showed that most associations were linear. Discussion: Maternal RBC metal and trace element concentrations were associated in a dose-dependent fashion with cord blood metabolites. What remains to be determined is whether these metals- and trace elements-associated changes in cord metabolites can influence a child’s risk of cardiometabolic diseases.Mingyu ZhangJessie P BuckleyLiming LiangXiumei HongGuoying WangMei-Cheng WangMarsha Wills-KarpXiaobin WangNoel T MuellerElsevierarticleHeavy metalsLeadMercuryCadmiumTrace elementsSeleniumEnvironmental sciencesGE1-350ENEnvironment International, Vol 158, Iss , Pp 106976- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heavy metals Lead Mercury Cadmium Trace elements Selenium Environmental sciences GE1-350
spellingShingle	Heavy metals Lead Mercury Cadmium Trace elements Selenium Environmental sciences GE1-350 Mingyu Zhang Jessie P Buckley Liming Liang Xiumei Hong Guoying Wang Mei-Cheng Wang Marsha Wills-Karp Xiaobin Wang Noel T Mueller A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort
description	Background: Exposure to metals lead (Pb), mercury (Hg), and cadmium (Cd) and trace elements selenium (Se) and manganese (Mn) has been linked to the developmental origins of cardiometabolic diseases, but the mechanisms are not well-understood. Objective: Conduct a metabolome-wide association study to understand how in utero exposure to Pb, Hg, Cd, Se, and Mn affects the metabolic programming of fetuses. Methods: We used data from the Boston Birth Cohort, which enrolled mother-child pairs from Boston, MA. We measured metals and trace elements in maternal red blood cells (RBCs) collected 24–72 h after delivery, and metabolites in cord blood collected at birth. We used multivariable linear regression to examine associations of metals and trace elements with metabolites and Bonferroni correction to account for multiple comparisons. We assessed non-linear associations of metals and trace elements with metabolites using restricted cubic spline plots. Results: This analysis included 670 mother-child pairs (57% non-Hispanic Black and 24% Hispanic). After Bonferroni correction, there were 25 cord metabolites associated with at least one of the metals or trace elements. Pb was negatively associated with the xenobiotic piperine, Cd was positively associated with xenobiotics cotinine and hydroxycotinine, and Hg was associated with 8 lipid metabolites (in both directions). Se and Mn shared associations with 6 metabolites (in both directions), which mostly included nucleotides and amino acids; Se was additionally associated with 7 metabolites (mostly amino acids, nucleotides, and carnitines) and Mn was additionally associated with C36:4 hydroxy phosphatidylcholine. Restricted cubic spline plots showed that most associations were linear. Discussion: Maternal RBC metal and trace element concentrations were associated in a dose-dependent fashion with cord blood metabolites. What remains to be determined is whether these metals- and trace elements-associated changes in cord metabolites can influence a child’s risk of cardiometabolic diseases.
format	article
author	Mingyu Zhang Jessie P Buckley Liming Liang Xiumei Hong Guoying Wang Mei-Cheng Wang Marsha Wills-Karp Xiaobin Wang Noel T Mueller
author_facet	Mingyu Zhang Jessie P Buckley Liming Liang Xiumei Hong Guoying Wang Mei-Cheng Wang Marsha Wills-Karp Xiaobin Wang Noel T Mueller
author_sort	Mingyu Zhang
title	A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort
title_short	A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort
title_full	A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort
title_fullStr	A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort
title_full_unstemmed	A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort
title_sort	metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: findings from the boston birth cohort
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/416180a622c04bcbab9b582ed8e13c8e
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A metabolome-wide association study of in utero metal and trace element exposures with cord blood metabolome profile: Findings from the Boston Birth Cohort

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